Peroxisome proliferator di-isodecyl phthalate has no carcinogenic potential in Fischer 344 rats

被引：14

作者：

Cho, Wan-Seob ^{[1
]}

Han, Beom Seok ^{[1
]}

Ahn, Byeongwoo ^{[2
]}

Nam, Ki Taek ^{[1
]}

Choi, Mina ^{[1
]}

Oh, Sang Yeon ^{[1
]}

Kim, Seung Hee ^{[1
]}

Jeong, Jayoung ^{[1
]}

Jang, Dong Deuk ^{[1
]}

机构：

[1] Korea FDA, Natl Inst Toxicol Res, Dept Toxicol Res, Div Toxicol Pathol, Seoul 122704, South Korea

[2] Chungbuk Natl Univ, Coll Vet Med, Dept Vet Pathol, Chungbuk 361763, South Korea

来源：

TOXICOLOGY LETTERS | 2008年 / 178卷 / 02期

关键词：

di-isodecyl phthalate (DIDP); peroxisome proliferator; carcinogenicity; liver; F344; rats; feed study;

D O I：

10.1016/j.toxlet.2008.02.013

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Di-isodecyl phthalate (DIDP), a peroxisome proliferator-activated receptor-alpha activator, is widely used as a plasticizer in the manufacture of polyvinyl chloride (PVC), and ultimately in typical vinyl applications, particularly wire, cable and toys, etc. To examine its carcinogenic potential, DIDP was fed to Fischer 344 rats in the diet at doses of 0, 400, 2000 and 8000 ppm for 2 years. Briefly, significant decreases in the overall survival and body weights, and increases in the relative weights of kidneys and liver were noted in both sexes of the highest dose groups. However, no treatment-related neoplastic lesions were observed in the internal organs, including the liver. Unlike di(2-ethylhexyl) phthalate (DEHP), DIDP failed to maintain the catalase-inducing potential between early and late expressions of catalase protein from western blotting, immunohistochemistry and enzyme activity measurements. These results suggest that the non-carcinogenicity of DIDP in F344 rats was due to its limited potential for peroxisomal proliferating activity. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：110 / 116

页数：7

共 38 条

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