Cholestane glycosides from the bulbs of Galtonia candicans and their cytotoxicity

被引：28

作者：

Kuroda, M ^{[1
]}

Mimaki, Y ^{[1
]}

Yokosuka, A ^{[1
]}

Sashida, Y ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Lab Med Plant Sci, Tokyo 1920392, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 08期

关键词：

Galtonia candicans; Liliaceae; cholestane glycoside; cytotoxic activity; HL-60; cell;

D O I：

10.1248/cpb.49.1042

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Further search for cytotoxic compounds contained in the bulbs of Galtonia candicans (Liliaceac) led to the isolation of four potent cytotoxic cholestane glycosides (1-4) based upon 3 beta ,16 beta ,17 alpha -trihydroxycholest-5-en-22-one, three of which (2-4) have not been reported previously. A new cholestane bisdesmoside (5) and a now rearranged cholestane glycoside (6) were also isolated. The structural assignment of the new constituents as carried out by spectroscopic analysis and a few chemical transformations.

引用

页码：1042 / 1046

页数：5

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