Microbiota, Obesity and NAFLD

被引：71
作者：
Lau, Louis H. S. [1 ,2 ]
Wong, Sunny H. [1 ,2 ]
机构：
[1] Chinese Univ Hong Kong, Inst Digest Dis, Dept Med & Therapeut, State Key Lab Digest Dis, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, LKS Inst Hlth Sci, Hong Kong, Peoples R China
来源：
OBESITY, FATTY LIVER AND LIVER CANCER | 2018年 / 1061卷
关键词：
Fatty liver; Microbiota; Intestinal inflammation; Gut permeability; Energy harvest; Insulin resistance; NONALCOHOLIC FATTY LIVER; DIET-INDUCED OBESITY; HUMAN GUT MICROBIOME; DE-NOVO LIPOGENESIS; INDUCED INSULIN-RESISTANCE; SMALL-INTESTINAL MOTILITY; BACTERIAL OVERGROWTH; HEPATIC STEATOSIS; S-NITROSATION; GREEN TEA;
D O I：
10.1007/978-981-10-8684-7_9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Non-alcoholic fatty liver disease (NAFLD) is an increasingly important cause of chronic liver disease globally. Similar to metabolic syndrome and obesity, NAFLD is associated with alternations in the gut microbiota and its related biological pathways. While the exact pathophysiology of NAFLD remains largely unknown, changes in intestinal inflammation, gut permeability, energy harvest, anaerobic fermentation and insulin resistance have been described. In this chapter, we review the relationship between the gut microbiota, obesity and NAFLD, and highlight potential ways to modify the gut microbiota to help managing NAFLD patients.
引用
收藏
页码：111 / 125
页数：15
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