Role of MTHFR 677 C>T Polymorphism on Blood Homocysteine and Susceptibility to Hypertension

被引：3
|
作者：
Dwivedi, M. K. [1 ]
Sinha, Deepak [2 ]
机构：
[1] Govt Nagarjuna Post Grad Coll Sci, Dept Biochem, Raipur, Chhattisgarh, India
[2] Govt Nagarjuna Post Grad Coll Sci, Dept Chem, Raipur, Chhattisgarh, India
来源：
INTERNATIONAL JOURNAL OF HUMAN GENETICS | 2017年 / 17卷 / 03期
关键词：
Endothelial Dysfunction; Free Radicals; Hyperhomocystenimia; Increased Blood Pressure; Lipid Per-oxidation; Polymorphism; METHYLENETETRAHYDROFOLATE-REDUCTASE GENE; C677T; MUTATION;
D O I：
10.1080/09723757.2017.1383619
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Genetic polymorphism of Methylenetetrahydrofolate reductase is found to associated with Stroke and other Cardiovascular diseases. This study analyzed Methylenetetrahydrofolate 677C>T polymorphism for association of blood homocysteine concentration and susceptibility to Hypertension in the Central Indian Population. This investigation has been conducted on 100 hypertensive cases and 223 healthy controls. 5ml blood sample has been taken from case and control and analyzed for blood homocysteine concentration by enzymatic assay and genotyping. The present study found statistically significant (P<0.0001) to establish hyperhomocystenimia is a risk factor for hypertension. The Methylenetetrahydrofolate 677C>T polymorphism is significantly (P<0.0001) associated with blood homocysteine level. The CT and TT genotype are showing association with hypertension susceptibility.
引用
收藏
页码：118 / 125
页数：8
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