Genotoxicity and Endocrine-Disruption Potentials of Sediment near an Oil Spill Site: Two Years after the Hebei Spirit Oil Spill

被引：54

作者：

Ji, Kyunghee ^{[1
]}

Seo, Jihyeon ^{[1
]}

Liu, Xiaoshan ^{[1
]}

Lee, Jinyoung ^{[1
]}

Lee, Sangwoo ^{[1
]}

Lee, Woojin ^{[2
]}

Park, Jeongim ^{[2
]}

Khim, Jong Seong ^{[3
]}

Hong, Seongjin ^{[3
]}

Choi, Yeyong ^{[4
]}

Shim, Won Joon ^{[5
]}

Takeda, Shunichi ^{[6
]}

Giesy, John P. ^{[7
,8
,9
,10
,11
,12
]}

Choi, Kyungho ^{[1
]}

机构：

[1] Seoul Natl Univ, Sch Publ Hlth, Seoul 151742, South Korea

[2] Soonchunhyang Univ, Coll Nat Sci, Asan 336745, South Korea

[3] Korea Univ, Div Environm Sci & Ecol Engn, Seoul 136713, South Korea

[4] Asian Citizens Ctr Environm Hlth, Seoul 110460, South Korea

[5] Korea Ocean Res & Dev Inst, Oil & POPs Res Grp, Geoje 656834, South Korea

[6] Kyoto Univ, Coll Med, Dept Radiat Genet, Kyoto 6068501, Japan

[7] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7J 5B3, Canada

[8] Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7J 5B3, Canada

[9] Michigan State Univ, Dept Zool, E Lansing, MI 48824 USA

[10] Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA

[11] King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia

[12] City Univ Hong Kong, Dept Biochem & Chem, Kowloon, Hong Kong, Peoples R China

来源：

ENVIRONMENTAL SCIENCE & TECHNOLOGY | 2011年 / 45卷 / 17期

关键词：

POLYCYCLIC AROMATIC-HYDROCARBONS; H295R CELLS; TOXICITY; STEROIDOGENESIS; DNA; CONTAMINANTS; EXPOSURE;

D O I：

10.1021/es200724x

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The Hebei Spirit oil spill episode (December 7, 2007) has affected the western coastal area of South Korea; however, there is limited information on the potential toxicity of the oil spill to the ecosystem or humans. The potential toxicity of sediments collected from the affected area (n = 22) 2 years after the spill was evaluated. Acute lethal toxicity tests using Vibrio fischeri and Moina macrocopa and tests for genotoxicity and alteration of steroidogenesis using chicken DT40 cells and H295R cells, respectively, were conducted. Both crude and weathered oil extracts were evaluated in order to link the observed toxicity in the sediment extracts to the oil spill. Whereas toxicity to bacteria and daphnids was observed in only two elutriate samples, 10 of the 22 sediment extracts showed genotoxic potential in DT40 cells. The mechanisms of genotoxicity involved nucleotide excision repair (XPA(-/)), homologous recombination (RAD54(-/-)), and translesion synthesis pathways (REV3(-/-)) In addition, nine sediment extracts caused significantly greater production of E2 in H295R cells, and significant upregulation of CYP19, CYP11B2, and 3 beta HSD2 by sediment extracts was observed. The pattern of toxicities observed in both crude and weathered oil samples was similar to that observed in the sediment extracts. The genotoxicicity and endocrine-disruption potential of the sediment extracts suggest a need for long-term followup for such toxicity in humans and wildlife in this area.

引用

页码：7481 / 7488

页数：8

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