FGFR Family Members Protein Expression as Prognostic Markers in Oral Cavity and Oropharyngeal Squamous Cell Carcinoma

被引：19

作者：

Koole, Koos ^{[1
,2
]}

Clausen, Martijn J. A. M. ^{[3
,4
]}

van Es, Robert J. J. ^{[2
]}

van Kempen, Pauline M. W. ^{[5
]}

Melchers, Lieuwe J. ^{[4
]}

Koole, Ron ^{[2
]}

Langendijk, Johannes A. ^{[6
]}

van Diest, Paul J. ^{[1
]}

Roodenburg, Jan L. N. ^{[4
]}

Schuuring, Ed ^{[3
]}

Willems, Stefan M. ^{[1
,7
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Pathol, H4-2-41,Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, UMC Utrecht Canc Ctr, Dept Head & Neck Surg Oncol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Hanzepl 1, NL-9713 GZ Groningen, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Oral & Maxillofacial Surg, Hanzepl 1, NL-9713 GZ Groningen, Netherlands

[5] Univ Med Ctr Utrecht, Dept Otorhinolaryngol Head & Neck Surg, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands

[6] Univ Groningen, Univ Med Ctr Groningen, Dept Radiat Oncol, Hanzepl 1, NL-9713 GZ Groningen, Netherlands

[7] Netherlands Canc Inst, Dept Mol Carcinogenesis, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands

来源：

MOLECULAR DIAGNOSIS & THERAPY | 2016年 / 20卷 / 04期

关键词：

FIBROBLAST-GROWTH-FACTOR; FACTOR RECEPTORS; NECK-CANCER; HEAD; COEXPRESSION; INHIBITOR; LESSONS;

D O I：

10.1007/s40291-016-0204-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Introduction Fibroblast growth factor receptor family member proteins (FGFR1-4) have been identified as promising novel therapeutic targets and prognostic markers in a wide spectrum of solid tumors. The present study investigates the expression and prognostic value of four FGFR family member proteins in a large multicenter oral cavity squamous cell carcinoma (OCSCC) and oropharyngeal squamous cell carcinoma (OPSCC) cohort. Methods Protein expression of FGFR1-4 was determined by immunohistochemistry on tissue microarrays containing 951 formalin-fixed paraffin embedded OCSCC and OPSCC tissues from the University Medical Center Utrecht and University Medical Center Groningen. Protein expression was correlated to overall survival using Cox regression models, and bootstrapping was performed as internal validation. Results FGFR proteins were highly expressed in 39-64 % of OCSCC and 63-79 % of OPSCC. Seventy-three percent (299/412) of OCSCC and 85 % (305/357) of OPSCC highly co-expressed two or more FGFR family member proteins. FGFR1 protein was more frequently highly expressed in human papillomavirus (HPV)-negative OPSCC than HPV-positive OPSCC (82 vs. 65 %; p = 0.008). Furthermore, protein expression of FGFR family members was not related to overall survival in OCSCC or OPSCC (p . 0.05). Conclusion FGFR family members are frequently highly expressed in OCSCC and OPSCC. These FGFR family member proteins are therefore potential targets for novel therapies that are urgently required to improve survival of OCSCC and OPSCC patients.

引用

页码：363 / 374

页数：12

共 33 条

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