Acetylcholinesterase activity and antioxidant capacity of zebrafish brain is altered by heavy metal exposure

被引：183

作者：

Richetti, S. K. ^{[2
]}

Rosemberg, D. B. ^{[3
]}

Ventura-Lima, J. ^{[4
]}

Monserrat, J. M. ^{[4
]}

Bogo, M. R. ^{[2
,5
]}

Bonan, C. D. ^{[1
,2
]}

机构：

[1] Pontificia Univ Catolica Rio Grande do Sul, Fac Biociencias, Dept Biol Celular & Mol, Lab Neuroquim & Psicofarmacol, BR-90619900 Porto Alegre, RS, Brazil

[2] INCT TM, BR-90035003 Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, BR-90035003 Porto Alegre, RS, Brazil

[4] Univ Fed Rio Grande, Inst Ciencias Biol, Rio Grande, RS, Brazil

[5] Pontificia Univ Catolica Rio Grande do Sul, Fac Biociencias, Lab Biol Genom & Mol, BR-90619900 Porto Alegre, RS, Brazil

来源：

NEUROTOXICOLOGY | 2011年 / 32卷 / 01期

关键词：

Heavy metal; Pollution; Acetylcholinesterase; Zebrafish; Oxidative stress; OXIDATIVE STRESS; NEURONAL DEATH; ZINC; EXPRESSION; MERCURY; GENE; LEAD; IMPAIRMENTS; ENVIRONMENT; MEDIATION;

D O I：

10.1016/j.neuro.2010.11.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pollution is a world problem with immeasurable consequences. Heavy metal compounds are frequently found as components of anthropogenic pollution. Here we evaluated the effects of the treatment with cadmium acetate, lead acetate, mercury chloride, and zinc chloride in acetylcholinesterase activity and gene expression pattern, as well as the effects of these treatments in antioxidant competence in the brain of an aquatic and well-established organism for toxicological analysis, zebrafish (Danio rerio, Cyprinidae). Mercury chloride and lead acetate promoted a significant decrease in acetylcholinesterase activity whereas they did not alter the gene expression pattern. In addition, the antioxidant competence was decreased after exposure to mercury chloride. The data presented here allowed us to hypothesize a signal transmission impairment, through alterations in cholinergic transmission, and also in the antioxidant competence of zebrafish brain tissue as some of the several effects elicited by these pollutants. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：116 / 122

页数：7

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