Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors

被引：27
作者：
Bordier, P
Garrigue, S
Barold, SS
Bressolles, N
Lanusse, S
Clémenty, J
机构：
[1] Univ Bordeaux, Hop Cardiol Haut Leveque, F-33604 Pessac, France
[2] Florida Cardiovasc Inst, Tampa, FL USA
[3] Tampa Gen Hosp, Tampa, FL 33606 USA
来源：
EUROPACE | 2003年 / 5卷 / 04期
关键词：
Alzheimer's disease; cholinesterase inhibitors; bradycardia;
D O I：
10.1016/S1099-5129(03)00080-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We describe three cases of patients with Alzheimer's disease who presented with cardiac syncope soon after initiation of a cholinesterase inhibitor therapy (donepezil). Bradyarrhythmia was documented in two patients, considered probable in one, and was presumed related to the cholinergic therapy. Pacemaker implantation seemed justified rather than donepezil cessation. More over, it permitted an increase in donepezil dosage. (C) 2003 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：429 / 431
页数：3
相关论文
共 16 条
[1]   Randomized, double-blind, placebo-controlled, multicenter study to evaluate the safety and tolerability of metrifonate in patients with probable Alzheimer disease [J].
Blass, JP ;
Cyrus, PA ;
Bieber, F ;
Gulanski, B .
ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2000, 14 (01) :39-45
[2]   Symptomatic sinus bradycardia associated with donepezil [J].
Calvo-Romero, JM ;
Ramos-Salado, JL .
REVISTA DE NEUROLOGIA, 1999, 28 (11) :1070-1072
[3]   Effect of patient characteristics on the yield of prolonged baseline head-up tilt testing and the additional yield of drug provocation [J].
Fitzpatrick, AP ;
Lee, RJ ;
Epstein, LM ;
Lesh, MD ;
Eisenberg, S ;
Scheinman, MM .
HEART, 1996, 76 (05) :406-411
[4]   Estimating the costs of caring for people with Alzheimer disease in California: 2000-2040 [J].
Fox, PJ ;
Kohatsu, N ;
Max, W ;
Arnsberger, P .
JOURNAL OF PUBLIC HEALTH POLICY, 2001, 22 (01) :88-97
[5]  
Fratiglioni L, 2000, NEUROLOGY, V54, pS10
[6]   Donepezil therapy in clinical practice -: A randomized crossover study [J].
Greenberg, SM ;
Tennis, MK ;
Brown, LB ;
Gomez-Isla, T ;
Hayden, DL ;
Schoenfeld, DA ;
Walsh, KL ;
Corwin, C ;
Daffner, KR ;
Friedman, P ;
Meadows, ME ;
Sperling, RA ;
Growdon, JH .
ARCHIVES OF NEUROLOGY, 2000, 57 (01) :94-99
[7]   Cholinesterase inhibitors for Alzheimer's disease [J].
Grutzendler, J ;
Morris, JC .
DRUGS, 2001, 61 (01) :41-52
[8]   Clinical efficacy and safety of donepezil on cognitive and global function in patients with Alzheimer's disease - A 24-week, multicenter, double-blind, placebo-controlled study in Japan [J].
Homma, A ;
Takeda, M ;
Imai, Y ;
Udaka, F ;
Hasegawa, K ;
Kameyama, M ;
Nishimura, T .
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2000, 11 (06) :299-313
[9]  
Lobo A, 2000, NEUROLOGY, V54, pS4
[10]   Maximum tolerated dose and pharmacodynamics of eptastigmine in elderly healthy volunteers [J].
Mant, T ;
Troetel, WM ;
Imbimbo, BP .
JOURNAL OF CLINICAL PHARMACOLOGY, 1998, 38 (07) :610-617
12