The Pif1p subfamily of helicases: region-specific DNA helicases?

被引：67

作者：

Bessler, JB ^{[1
]}

Torres, JZ ^{[1
]}

Zakian, VA ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

TRENDS IN CELL BIOLOGY | 2001年 / 11卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0962-8924(00)01877-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA helicases are required for DNA replication, recombination and repair. Despite a common enzymatic function - the ability to unwind duplex DNA most helicases share only limited amino acid sequence similarity. Helicases that have significant sequence similarity define a subfamily. It remains unclear, however, how this sequence similarity relates to helicase function. The Saccharomyces cerevisiae Pif1p helicase is the prototype member of a helicase subfamily that is conserved from yeasts to humans. As the two Pif1p subfamily members studied to date affect the same DNA sequences, the amino acid similarity that defines this subfamily might reflect common substrates.

引用

页码：60 / 65

页数：6

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