A new CTGF target in renal fibrosis

被引：24
作者：
Montford, John R. [1 ,2 ]
Furgeson, Seth B. [1 ,3 ,4 ]
机构：
[1] Univ Colorado, Div Renal Dis & Hypertens, Anschutz Med Campus, Aurora, CO USA
[2] Denver Vet Affairs Med Ctr, Renal Sect, Denver, CO USA
[3] Denver Hlth Hosp, Dept Med, Denver, CO USA
[4] Univ Colorado, Consortium Fibrosis Res & Translat, Anschutz Med Campus, Aurora, CO USA
来源：
KIDNEY INTERNATIONAL | 2017年 / 92卷 / 04期
关键词：
TISSUE GROWTH-FACTOR; TUBULOINTERSTITIAL FIBROSIS; KIDNEY-DISEASE;
D O I：
10.1016/j.kint.2017.04.042
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Lymphangiogenesis appears to accompany renal fibrosis, but signals that regulate the lymphangiogenic growth factor vascular endothelial growth factor C are not well understood. Kinashi et al. have shown that conditionally deleting connective tissue growth factor reduces renal fibrosis, vascular endothelial growth factor C, and lymphangiogenesis. Connective tissue growth factor has pleiotropic effects in the setting of renal fibrosis; this study adds a potentially new mechanism for the profibrotic effects of connective tissue growth factor. Copyright (C) 2017, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：784 / 786
页数：4
相关论文
共 9 条
[1]   Regardless of etiology, progressive renal disease causes ultrastructural and functional alterations of peritubular capillaries [J].
Babickova, Janka ;
Klinkhammer, Barbara M. ;
Buhl, Eva M. ;
Djudjaj, Sonja ;
Hoss, Mareike ;
Heymann, Felix ;
Tacke, Frank ;
Floege, Juergen ;
Becker, Jan U. ;
Boor, Peter .
KIDNEY INTERNATIONAL, 2017, 91 (01) :70-85
[2]   Peritubular capillary loss is associated with chronic tubulointerstitial injury in human kidney: Altered expression of vascular endothelial growth factor [J].
Choi, YJ ;
Chakraborty, S ;
Nguyen, V ;
Nguyen, C ;
Kim, BK ;
Shim, SI ;
Suki, WN ;
Truong, LD .
HUMAN PATHOLOGY, 2000, 31 (12) :1491-1497
[3]   Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis [J].
Inoki, I ;
Shiomi, T ;
Hashimoto, G ;
Enomoto, H ;
Nakamura, H ;
Makino, K ;
Ikeda, E ;
Takata, S ;
Kobayashi, K ;
Okada, Y .
FASEB JOURNAL, 2001, 15 (14) :219-+
[4]   Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor-Related Protein 6 [J].
Johnson, Bryce G. ;
Ren, Shuyu ;
Karaca, Gamze ;
Gomez, Ivan G. ;
Fligny, Cecile ;
Smith, Benjamin ;
Ergun, Ayla ;
Locke, George ;
Gao, Benbo ;
Hayes, Sebastian ;
MacDonnell, Scott ;
Duffield, Jeremy S. .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2017, 28 (06) :1769-1782
[5]   Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis [J].
Kinashi, Hiroshi ;
Falke, Lucas L. ;
Nguyen, Tri Q. ;
Bovenschen, Niels ;
Aten, Jan ;
Leask, Andrew ;
Ito, Yasuhiko ;
Goldschmeding, Roel .
KIDNEY INTERNATIONAL, 2017, 92 (04) :850-863
[6]   Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease [J].
Kok, Helena M. ;
Falke, Lucas L. ;
Goldschmeding, Roel ;
Nguyen, Tri Q. .
NATURE REVIEWS NEPHROLOGY, 2014, 10 (12) :700-711
[7]   Lymphatic vessels develop during tubulointerstitial fibrosis [J].
Sakamoto, Izumi ;
Ito, Yasuhiko ;
Mizuno, Masashi ;
Suzuki, Yasuhiro ;
Sawai, Akiho ;
Tanaka, Akio ;
Maruyama, Shoichi ;
Takei, Yoshifumi ;
Yuzawa, Yukio ;
Matsuo, Seiichi .
KIDNEY INTERNATIONAL, 2009, 75 (08) :828-838
[8]   Lymphangiogenesis in renal diseases: passive bystander or active participant? [J].
Yazdani, Saleh ;
Navis, Gerjan ;
Hillebrands, Jan-Luuk ;
van Goor, Harry ;
van den Born, Jacob .
EXPERT REVIEWS IN MOLECULAR MEDICINE, 2014, 16
[9]   Reduction in connective tissue growth factor by antisense treatment ameliorates renal tubulointerstitial fibrosis [J].
Yokoi, H ;
Mukoyama, M ;
Nagae, T ;
Mori, K ;
Suganami, T ;
Sawai, K ;
Yoshioka, T ;
Koshikawa, M ;
Nishida, T ;
Takigawa, M ;
Sugawara, A ;
Nakao, K .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2004, 15 (06) :1430-1440
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