Circulating vitamin E levels and Alzheimer's disease: a Mendelian randomization study

被引：56

作者：

Liu, Guiyou ^{[1
]}

Zhao, Yi ^{[2
]}

Jin, Shuilin ^{[3
]}

Hu, Yang ^{[1
]}

Wang, Tao ^{[1
]}

Tian, Rui ^{[1
]}

Han, Zhifa ^{[1
]}

Xu, Dandan ^{[4
]}

Jiang, Qinghua ^{[1
]}

机构：

[1] Harbin Inst Technol, Sch Life Sci & Technol, Room 415,Bldg 2E,Sci Pk,Yikuang St, Harbin 150080, Heilongjiang, Peoples R China

[2] Taishan Med Univ, Affiliated Hosp, Tai An, Shandong, Peoples R China

[3] Harbin Inst Technol, Dept Math, Harbin, Heilongjiang, Peoples R China

[4] Harbin Univ, Fac Sci, Dept Biol, Harbin, Heilongjiang, Peoples R China

来源：

NEUROBIOLOGY OF AGING | 2018年 / 72卷

基金：

美国国家卫生研究院; 英国医学研究理事会; 中国国家自然科学基金; 英国惠康基金;

关键词：

Alzheimer's disease; Vitamin E; Genome-wide association study; Mendelian randomization; GENOME-WIDE ASSOCIATION; POLYMORPHISM CONTRIBUTES; LOCI; SUSCEPTIBILITY; METAANALYSIS; EXPRESSION; CHINESE; TRIAL; ONSET;

D O I：

10.1016/j.neurobiolaging.2018.08.008

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Alzheimer's disease (AD) is the leading cause of dementia in older adults. It is more than 50 years since vitamin E was recognized as critical for optimal neurological health. Clinical studies have yielded inconsistent findings on the effect of vitamin E on AD risk. Thus, it remains unclear whether vitamin E levels are genetically associated with AD risk. We performed a Mendelian randomization study to investigate association of circulating vitamin E levels with AD using large-scale vitamin E genome-wide association study data set (N = 7781 individuals of European descent) and AD genome-wide association study data set (N = 54,162 individuals [ including 17,008 AD cases and 37,154 controls of European descent]). Mendelian randomization-Egger intercept test showed no significant pleiotropy (beta = -0.113; p = 0.296). Inverse-variance weighted (odds ratio = 0.96, 95% confidence interval: 0.47-1.94, p = 0.936) and weighted median analyses (odds ratio = 1.13, 95% confidence interval: 0.35-3.69, p = 0.836) showed no significant association between vitamin E and AD. Together with previous literature, this suggests that vitamin E supplementation may not forestall AD in the general population. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：189.e1 / 189.e9

页数：9

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