Biocompatible conjugated polymer nanoparticles for highly efficient photoacoustic imaging of orthotopic brain tumors in the second near-infrared window

被引：127

作者：

Guo, Bing ^{[1
]}

Sheng, Zonghai ^{[2
]}

Kenry ^{[1
]}

Hu, Dehong ^{[2
]}

Lin, Xiangwei ^{[3
]}

Xu, Shidang ^{[1
]}

Liu, Chengbo ^{[3
]}

Zheng, Hairong ^{[2
]}

Liu, Bin ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore

[2] Chinese Acad Sci, Paul C Lauterbur Res Ctr Biomed Imaging, Inst Biomed & Hlth Engn, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China

[3] Chinese Acad Sci, Res Lab Biomed Opt & Mol Imaging, Shenzhen Key Lab Mol Imaging, Inst Biomed & Hlth Engn,Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China

来源：

MATERIALS HORIZONS | 2017年 / 4卷 / 06期

关键词：

CONTRAST AGENT; 1064; NM; NANOMATERIALS; NANOSHEETS; MODEL; LASER;

D O I：

10.1039/c7mh00672a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new second near-infrared (NIR II) conjugated polymer (CP) was designed and synthesized. The CP nanoparticles have good biocompatibility, excellent photostability and high imaging contrast, and have been successfully used to demonstrate the first example of NIR II photoacoustic imaging of orthotopic brain tumors. In comparison with existing contrast agents for photoacoustic imaging, the NIR II CP nanoparticles showed more efficient skull penetration and a much higher signal/background ratio using a 1064 nm laser.

引用

页码：1151 / 1156

页数：6

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