Biocompatible conjugated polymer nanoparticles for highly efficient photoacoustic imaging of orthotopic brain tumors in the second near-infrared window

被引：127
|
作者：
Guo, Bing [1 ]
Sheng, Zonghai [2 ]
Kenry [1 ]
Hu, Dehong [2 ]
Lin, Xiangwei [3 ]
Xu, Shidang [1 ]
Liu, Chengbo [3 ]
Zheng, Hairong [2 ]
Liu, Bin [1 ]
机构：
[1] Natl Univ Singapore, Dept Chem & Biomol Engn, 4 Engn Dr 4, Singapore 117585, Singapore
[2] Chinese Acad Sci, Paul C Lauterbur Res Ctr Biomed Imaging, Inst Biomed & Hlth Engn, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
[3] Chinese Acad Sci, Res Lab Biomed Opt & Mol Imaging, Shenzhen Key Lab Mol Imaging, Inst Biomed & Hlth Engn,Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
来源：
MATERIALS HORIZONS | 2017年 / 4卷 / 06期
关键词：
CONTRAST AGENT; 1064; NM; NANOMATERIALS; NANOSHEETS; MODEL; LASER;
D O I：
10.1039/c7mh00672a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new second near-infrared (NIR II) conjugated polymer (CP) was designed and synthesized. The CP nanoparticles have good biocompatibility, excellent photostability and high imaging contrast, and have been successfully used to demonstrate the first example of NIR II photoacoustic imaging of orthotopic brain tumors. In comparison with existing contrast agents for photoacoustic imaging, the NIR II CP nanoparticles showed more efficient skull penetration and a much higher signal/background ratio using a 1064 nm laser.
引用
收藏
页码：1151 / 1156
页数：6
相关论文
共 50 条
  • [11] Ultrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window
    Hong, Guosong
    Zou, Yingping
    Antaris, Alexander L.
    Diao, Shuo
    Wu, Di
    Cheng, Kai
    Zhang, Xiaodong
    Chen, Changxin
    Liu, Bo
    He, Yuehui
    Wu, Justin Z.
    Yuan, Jun
    Zhang, Bo
    Tao, Zhimin
    Fukunaga, Chihiro
    Dai, Hongjie
    NATURE COMMUNICATIONS, 2014, 5
  • [12] Ratiometric Optical and Photoacoustic Imaging In Vivo in the Second Near-Infrared Window
    Zhu, Kang
    Zhang, Xuan
    Wu, Ying
    Song, Jibin
    ACCOUNTS OF CHEMICAL RESEARCH, 2023, 56 (22) : 3223 - 3234
  • [13] Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy
    Chen, Haobin
    Zhang, Jian
    Chang, Kaiwen
    Men, Xiaoju
    Fang, Xiaofeng
    Zhou, Libo
    Li, Dongliang
    Gao, Duyang
    Yin, Shengyan
    Zhang, Xuanjun
    Yuan, Zhen
    Wu, Changfeng
    BIOMATERIALS, 2017, 144 : 42 - 52
  • [14] Organic Semiconducting Polymer Nanoparticles for Photoacoustic Labeling and Tracking of Stem Cells in the Second Near-Infrared Window
    Yin, Chao
    Wen, Guohua
    Liu, Chao
    Yang, Boguang
    Lin, Sien
    Huang, Jiawei
    Zhao, Pengchao
    Wong, Siu Hong Dexter
    Zhang, Kunyu
    Chen, Xiaoyu
    Li, Gang
    Jiang, Xiaohua
    Huang, Jianping
    Pu, Kanyi
    Wang, Lidai
    Bian, Liming
    ACS NANO, 2018, 12 (12) : 12201 - 12211
  • [15] In vivo photoacoustic lipid imaging in mice using the second near-infrared window
    Sangha, Gurneet S.
    Phillips, Evan H.
    Goergen, Craig J.
    BIOMEDICAL OPTICS EXPRESS, 2017, 8 (02): : 736 - 742
  • [16] Ambient Oxygen-Doped Conjugated Polymer for pH-Activatable Aggregation-Enhanced Photoacoustic Imaging in the Second Near-Infrared Window
    Wu, Jiayingzi
    You, Liyan
    Chaudhry, Saadia T.
    He, Jiazhi
    Cheng, Ji-Xin
    Mei, Jianguo
    ANALYTICAL CHEMISTRY, 2021, 93 (06) : 3189 - 3195
  • [17] Benzobisthiadiazole and Its Derivative-Based Semiconducting Polymer Nanoparticles for Second Near-Infrared Photoacoustic Imaging
    Huang, Xuelong
    Lan, Ning
    Zhang, Yanfeng
    Zeng, Wei
    He, Haifeng
    Liu, Xiuhong
    FRONTIERS IN CHEMISTRY, 2022, 10
  • [18] Photoacoustic Imaging and Photothermal Therapy of Semiconducting Polymer Nanoparticles: Signal Amplification and Second Near-Infrared Construction
    Zhen, Xu
    Pu, Kanyi
    Jiang, Xiqun
    SMALL, 2021, 17 (06)
  • [19] Molecular Imaging in the Second Near-Infrared Window
    Wan, Hao
    Du, Haotian
    Wang, Feifei
    Dai, Hongjie
    ADVANCED FUNCTIONAL MATERIALS, 2019, 29 (25)
  • [20] Miniature gold nanorods for photoacoustic molecular imaging in the second near-infrared optical window
    Chen, Yun-Sheng
    Zhao, Yang
    Yoon, Soon Joon
    Gambhir, Sanjiv Sam
    Emelianov, Stanislav
    NATURE NANOTECHNOLOGY, 2019, 14 (05) : 465 - 472
12345