Molecular profiling in diffuse large B-cell lymphoma: why so many types of subtypes?

被引：68

作者：

Morin, Ryan D. ^{[1
,2
,3
]}

Arthur, Sarah E. ^{[1
,3
]}

Hodson, Daniel J. ^{[4
,5
]}

机构：

[1] Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC, Canada

[2] BC Canc, Genome Sci Ctr, Vancouver, BC, Canada

[3] BC Canc Ctr Lymphoid Canc, Vancouver, BC, Canada

[4] Wellcome MRC Cambridge Stem Cell Inst, Cambridge Biomed Campus, Cambridge, England

[5] Univ Cambridge, Dept Haematol, Cambridge CB20AW, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2022年 / 196卷 / 04期

基金：

英国惠康基金;

关键词：

lymphomas; diffuse large B-cell lymphoma; cancer genetics; mutation analysis; classifications; DOUBLE-HIT LYMPHOMA; PHASE-III TRIAL; GENE-EXPRESSION; CODING GENOME; SOMATIC MUTATIONS; EZH2; MUTATIONS; PRIMARY BREAST; R-CHOP; SURVIVAL; PROMOTES;

D O I：

10.1111/bjh.17811

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The term diffuse large B-cell lymphoma (DLBCL) includes a heterogeneous collection of biologically distinct tumours. This heterogeneity currently presents a barrier to the successful deployment of novel, biologically targeted therapies. Molecular profiling studies have recently proposed new molecular classification systems. These have the potential to resolve the biological heterogeneity of DLBCL into manageable subgroups of tumours that rely on shared oncogenic programmes. In many cases these biological programmes straddle the boundaries of our existing systems for classifying B-cell lymphomas. Here we review the findings from these major molecular profiling studies with a specific focus on those that propose new genetic subgroups of DLBCL. We highlight the areas of consensus and discordance between these studies and discuss the implications for current clinical practice and for clinical trials. Finally, we address the outstanding challenges and solutions to the introduction of genomic subtyping and precision medicine in DLBCL.

引用

页码：814 / 829

页数：16

共 75 条

[1] Comparative analysis of gene expression platforms for cell-of-origin classification of diffuse large B-cell lymphoma shows high concordance [J].

Ahmed, Sophia ;

Glover, Paul ;

Taylor, Jan ;

Sha, Chulin ;

Care, Matthew A. ;

Tooze, Reuben ;

Davies, Andrew ;

Westhead, David R. ;

Johnson, Peter W. M. ;

Burton, Catherine ;

Barrans, Sharon L. .

BRITISH JOURNAL OF HAEMATOLOGY, 2021, 192 (03) :599-604

[2] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[3] Distinct subtypes of diffuse large B-cell lymphoma defined by hypermutated genes [J].

Alkodsi, Amjad ;

Cervera, Alejandra ;

Zhang, Kaiyang ;

Louhimo, Riku ;

Meriranta, Leo ;

Pasanen, Annika ;

Leivonen, Suvi-Katri ;

Holte, Harald ;

Leppa, Sirpa ;

Lehtonen, Rainer ;

Hautaniemi, Sampsa .

LEUKEMIA, 2019, 33 (11) :2662-2672

[4] Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma [J].

Arthur, Sarah E. ;

Jiang, Aixiang ;

Grande, Bruno M. ;

Alcaide, Miguel ;

Cojocaru, Razvan ;

Rushton, Christopher K. ;

Mottok, Anja ;

Hilton, Laura K. ;

Lat, Prince Kumar ;

Zhao, Eric Y. ;

Culibrk, Luka ;

Ennishi, Daisuke ;

Jessa, Selin ;

Chong, Lauren ;

Thomas, Nicole ;

Pararajalingam, Prasath ;

Meissner, Barbara ;

Boyle, Merrill ;

Davidson, Jordan ;

Bushell, Kevin R. ;

Lai, Daniel ;

Farinha, Pedro ;

Slack, Graham W. ;

Morin, Gregg B. ;

Shah, Sohrab ;

Sen, Dipankar ;

Jones, Steven J. M. ;

Mungall, Andrew J. ;

Gascoyne, Randy D. ;

Audas, Timothy E. ;

Unrau, Peter ;

Marra, Marco A. ;

Connors, Joseph M. ;

Steidl, Christian ;

Scott, David W. ;

Morin, Ryan D. .

NATURE COMMUNICATIONS, 2018, 9

[5]

Arthur SE., 2021, NONCODING NFKBIZ 3 U, DOI [10.1101/2021.05.22.445261, DOI 10.1101/2021.05.22.445261]

[6] EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation [J].

Beguelin, Wendy ;

Popovic, Relja ;

Teater, Matt ;

Jiang, Yanwen ;

Bunting, Karen L. ;

Rosen, Monica ;

Shen, Hao ;

Yang, Shao Ning ;

Wang, Ling ;

Ezponda, Teresa ;

Martinez-Garcia, Eva ;

Zhang, Haikuo ;

Zheng, Yupeng ;

Verma, Sharad K. ;

McCabe, Michael T. ;

Ott, Heidi M. ;

Van Aller, Glenn S. ;

Kruger, Ryan G. ;

Liu, Yan ;

McHugh, Charles F. ;

Scott, David W. ;

Chung, Young Rock ;

Kelleher, Neil ;

Shaknovich, Rita ;

Creasy, Caretha L. ;

Gascoyne, Randy D. ;

Wong, Kwok-Kin ;

Cerchietti, Leandro ;

Levine, Ross L. ;

Abdel-Wahab, Omar ;

Licht, Jonathan D. ;

Elemento, Olivier ;

Melnick, Ari M. .

CANCER CELL, 2013, 23 (05) :677-692

[7] EZH2 mutations are frequent and represent an early event in follicular lymphoma [J].

Boedoer, Csaba ;

Grossmann, Vera ;

Popov, Nikolay ;

Okosun, Jessica ;

O'Riain, Ciaran ;

Tan, King ;

Marzec, Jacek ;

Araf, Shamzah ;

Wang, Jun ;

Lee, Abigail M. ;

Clear, Andrew ;

Montoto, Silvia ;

Matthews, Janet ;

Iqbal, Sameena ;

Rajnai, Hajnalka ;

Rosenwald, Andreas ;

Ott, German ;

Campo, Elias ;

Rimsza, Lisa M. ;

Smeland, Erlend B. ;

Chan, Wing C. ;

Braziel, Rita M. ;

Staudt, Louis M. ;

Wright, George ;

Lister, T. Andrew ;

Elemento, Olivier ;

Hills, Robert ;

Gribben, John G. ;

Chelala, Claude ;

Matolcsy, Andras ;

Kohlmann, Alexander ;

Haferlach, Torsten ;

Gascoyne, Randy D. ;

Fitzgibbon, Jude .

BLOOD, 2013, 122 (18) :3165-3168

[8] Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis [J].

Caganova, Marieta ;

Carrisi, Chiara ;

Varano, Gabriele ;

Mainoldi, Federica ;

Zanardi, Federica ;

Germain, Pierre-Luc ;

George, Laura ;

Alberghini, Federica ;

Ferrarini, Luca ;

Talukder, Asoke K. ;

Ponzoni, Maurilio ;

Testa, Giuseppe ;

Nojima, Takuya ;

Doglioni, Claudio ;

Kitamura, Daisuke ;

Toellner, Kai-M. ;

Su, I-hsin ;

Casola, Stefano .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (12) :5009-5022

[9] Patients with primary breast and primary female genital tract diffuse large B cell lymphoma have a high frequency of MYD88 and CD79B mutations [J].

Cao, Xin-xin ;

Li, Jian ;

Cai, Hao ;

Zhang, Wei ;

Duan, Ming-hui ;

Zhou, Dao-bin .

ANNALS OF HEMATOLOGY, 2017, 96 (11) :1867-1871

[10] A Microarray Platform-Independent Classification Tool for Cell of Origin Class Allows Comparative Analysis of Gene Expression in Diffuse Large B-cell Lymphoma [J].

Care, Matthew A. ;

Barrans, Sharon ;

Worrillow, Lisa ;

Jack, Andrew ;

Westhead, David R. ;

Tooze, Reuben M. .

PLOS ONE, 2013, 8 (02)

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