Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells

被引：8

作者：

Fujihara, Koji ^{[1
]}

Takahashi, Kunio ^{[1
]}

Koyama, Kiyotaka ^{[1
]}

Kinoshita, Kaoru ^{[1
]}

机构：

[1] Meiji Pharmaceut Univ, Dept Pharmacognosy & Phytochem, 2-522-1 Noshio, Kiyose, Tokyo 2048588, Japan

来源：

JOURNAL OF NATURAL MEDICINES | 2017年 / 71卷 / 04期

关键词：

Cactus; Polaskia chichipe; Saponins; Melanin; B16; Chichipegenin; Oleanolic acid; Chichipenoside; TRICHOCEREUS-PACHANOI; STENOCEREUS-ERUCA; OLEANOLIC ACID; TERPENOIDS; CACTUS; LONGISPINOGENIN; CACTACEAE; PLANTS;

D O I：

10.1007/s11418-017-1082-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new oleanane-type saponins 1-5 together with a known saponin 6 and a steroidal glycoside 7 were isolated from Polaskia chichipe Backbg., and their structures were determined from their 1D and 2D NMR and HRFABMS spectral data. The six isolated saponins 1-6 were tested for their effects on the melanogenesis of B16 melanoma 4A5 cells. Compound 1 exerted an inhibitory effect at 100 mu M whereas compound 3 promoted melanogenesis at the same concentration, even though these two compounds contain the same aglycon structure. The dose-dependent activities of compounds 1 and 3 on melanin synthesis were investigated.

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收藏

页码：606 / 616

页数：11

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