Long non-coding RNA PCAT1 promotes cell migration and invasion in human laryngeal cancer by sponging miR-210-3p

被引：5

作者：

Hu, Weiqun ^{[1
]}

Dong, Na ^{[2
]}

Huang, Jinqiao ^{[1
]}

Ye, Ben ^{[3
]}

机构：

[1] Putian Univ, Dept Otolaryngol, Affiliated Hosp, Putian 351100, Peoples R China

[2] Weifang Yidu Cent Hosp, Dept Orthoped Spinal Trauma, Weifang 262500, Peoples R China

[3] Shandong First Med Univ, Shandong Prov Hosp, Dept Otorhinolaryngol, 324 Jingwu Rd, Jinan 250000, Shandong, Peoples R China

来源：

JOURNAL OF BUON | 2019年 / 24卷 / 06期

关键词：

Long non-coding RNA; PCAT1; laryngeal cancer; miR-210-3p; PROLIFERATION; CHEMOTHERAPY; METASTASIS; RESISTANCE; LINKS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Laryngeal cancer (LC) is one of the most ordinary head and neck cancers worldwide. In this study, the role of long non-coding RNA (lncRNA) PCAT1 in LC was explored. Methods: PCAT1 expression in 50 paired tissue samples from LC patients was monitored by real-time quantitative polymerase chain reaction (RT-qPCR). Afterwards, function assays were conducted to explore how PCATI participated in metastasis of LC in vitro and in vivo. Then, bio-information software and luciferase assay were utilized to predict the possible target microRNA (miR) of PCAT1 in LC. Results: PCAT1 was obviously upregulated in LC tissues compared with adjacent tissues. Knockdown of PCAT1 inhibited the ability of cell migration and invasion in LC. Moreover, knockdown of PCAT1 inhibited tumor formation in vivo. Furthermore, miR-210-3p was sponged by PCAT1 in LC cells. Conclusion: PCAT1 was first identified as a novel oncogene in LC and could promote LC cell migration and invasion by sponging miR-210-3p.

引用

页码：2429 / 2434

页数：6

共 16 条

[1] Andreadis C, 2007, J BUON, V12, P341
[2] Dincer M, 2012, J BUON, V17, P337
[3] Li H, 2017, TUMOR BIOL, V39
[4] Down-regulation of miR-210-3p encourages chemotherapy resistance of renal cell carcinoma via modulating ABCC1
Li, Songchao
Yang, Jinjian
Wang, Jun
Gao, Wansheng
Ding, Yafei
Ding, Yinghui
Jia, Zhankui
[J]. CELL AND BIOSCIENCE, 2018, 8
[5] Exosomal long noncoding RNA CRNDE-h as a novel serum-based biomarker for diagnosis and prognosis of colorectal cancer
Liu, Tong
Zhang, Xin
Gao, Shanyu
Jing, Fangmiao
Yang, Yongmei
Du, Lutao
Zheng, Guixi
Li, Peilong
Li, Chen
Wang, Chuanxin
[J]. ONCOTARGET, 2016, 7 (51) : 85551 - 85563
[6] Ma TT, 2018, EUR REV MED PHARMACO, V22, P1907, DOI 10.26355/eurrev_201804_14713
[7] The Long Non-Coding RNA PCAT-1 Promotes Prostate Cancer Cell Proliferation through cMyc
Prensner, John R.
Chen, Wei
Han, Sumin
Iyer, Matthew K.
Cao, Qi
Kothari, Vishal
Evans, Joseph R.
Knudsen, Karen E.
Paulsen, Michelle T.
Ljungman, Mats
Lawrence, Theodore S.
Chinnaiyan, Arulm.
Feng, Felix Y.
[J]. NEOPLASIA, 2014, 16 (11): : 900 - 908
[8] Knockdown of long non-coding RNA prostate cancer-associated ncRNA transcript 1 inhibits multidrug resistance and c-Myc-dependent aggressiveness in colorectal cancer Caco-2 and HT-29 cells
Qiao, Lei
Liu, Xiangyu
Tang, Yichao
Zhao, Zheng
Zhang, Jilong
Liu, Huayan
[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2018, 441 (1-2) : 99 - 108
[9] The long noncoding RNA PCAT-1 links the microRNA miR-215 to oncogene CRKL-mediated signaling in hepatocellular carcinoma
Ren, Yanli
Shang, Jinhua
Li, Jinliang
Liu, Wenjuan
Zhang, Zhao
Yuan, Jupeng
Yang, Ming
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (43) : 17939 - 17949
[10] miR-30a-5p together with miR-210-3p as a promising biomarker for non-small cell lung cancer: A preliminary study
Switlik, Weronika
Karbownik, Michal Seweryn
Suwalski, Michal
Kozak, Jozef
Szemraj, Janusz
[J]. CANCER BIOMARKERS, 2018, 21 (02) : 479 - 488

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