Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Arylglycines

被引:40
作者
Beisel, Tamara [1 ]
Diehl, Andreas M. [1 ]
Manolikakes, Georg [1 ]
机构
[1] Goethe Univ Frankfurt, Dept Organ Chem & Chem Biol, Max von Laue Str 7, D-60438 Frankfurt, Germany
关键词
N-TERT-BUTANESULFINYL; ASYMMETRIC MULTICOMPONENT REACTIONS; BORONO-MANNICH REACTION; AMINO-ACID DERIVATIVES; PETASIS-TYPE REACTION; ARYLBORONIC ACIDS; IMINO ESTERS; ADDITION-REACTIONS; ALPHA; BETA-UNSATURATED KETONES; ORGANOBORON REAGENTS;
D O I
10.1021/acs.orglett.6b02045
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A general Pd-catalyzed, enantioselective three-component synthesis of alpha-arylglycines starting from sulfonamides, glyoxylic acid derivatives, and boronic acids was developed. This operationally straightforward procedure enables the preparation of a wide variety of a-arylglycines in high yields and excellent levels of enantioselectivity from a simple set of readily available starting materials. Incorporation of Pbf-amides gives a racemization-free access to N-unprotected alpha-arylglycines.
引用
收藏
页码:4116 / 4119
页数:4
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