Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Arylglycines

被引：40

作者：

Beisel, Tamara ^{[1
]}

Diehl, Andreas M. ^{[1
]}

Manolikakes, Georg ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Dept Organ Chem & Chem Biol, Max von Laue Str 7, D-60438 Frankfurt, Germany

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 16期

关键词：

N-TERT-BUTANESULFINYL; ASYMMETRIC MULTICOMPONENT REACTIONS; BORONO-MANNICH REACTION; AMINO-ACID DERIVATIVES; PETASIS-TYPE REACTION; ARYLBORONIC ACIDS; IMINO ESTERS; ADDITION-REACTIONS; ALPHA; BETA-UNSATURATED KETONES; ORGANOBORON REAGENTS;

D O I：

10.1021/acs.orglett.6b02045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general Pd-catalyzed, enantioselective three-component synthesis of alpha-arylglycines starting from sulfonamides, glyoxylic acid derivatives, and boronic acids was developed. This operationally straightforward procedure enables the preparation of a wide variety of a-arylglycines in high yields and excellent levels of enantioselectivity from a simple set of readily available starting materials. Incorporation of Pbf-amides gives a racemization-free access to N-unprotected alpha-arylglycines.

引用

收藏

页码：4116 / 4119

页数：4

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