Serine protease inhibition and modulatory-antibiotic activity of the proteic extract and fractions from Amburana cearensis

被引：9

作者：

Oliveira, Maria T. A. ^{[1
,2
]}

Moura, Geovanna M. M. ^{[1
]}

da Cruz, Joelton I. O. ^{[1
]}

Lima, Rayanna V. C. ^{[1
]}

dos Santos, Elizeu A. ^{[1
]}

Andrade, Jacqueline C. ^{[3
]}

Alencar, Marcus V. O. B. ^{[2
]}

Landim, Vicente P. A. ^{[2
]}

Coutinho, Henrique D. M. ^{[4
]}

Uchoa, Adriana F. ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Norte, Lab Quim & Funcao Proteinas Bioat, BR-59072970 Natal, RN, Brazil

[2] Ctr Univ INTA UNINTA, Dept Biomed, BR-62050100 Sobral, CE, Brazil

[3] Univ Fed Cariri UFCA, Inst Formacao Educ, Lab Bioensaios LABIO, Campus Brejo Santo, BR-63048080 Brejo Santo, Ceara, Brazil

[4] Univ Reg Cariri URCA, LMBM, BR-63105000 Crato, CE, Brazil

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2020年 / 135卷

关键词：

Bacterial resistance; Antibiotics; Modulating effect; Trypsin inhibitor; Amburana cearensis; ESCHERICHIA-COLI; ANTIBACTERIAL;

D O I：

10.1016/j.fct.2019.110946

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study investigated the inhibitory activity of serine protease, as well as antibacterial and antibiotic modifying activities of the crude extract and fractions of A. cearensis seeds. Microdilution assay was used to evaluate the antibacterial activity and the antibiotic resistance-modulating effects of samples against multiresistant bacteria Staphylococcus aureus (SA10) and Escherichia coli (EC06). In the inhibition test for serine protease, all the samples showed inhibition of enzymatic activity. Crude extract and fractions of A. cearensis seeds showed a Minimum Inhibitory Concentration >= 1024 mu g/mL for all microorganisms tested. However, the samples acted as resistance modifying agent, presenting synergism when associated with gentamicin, norfloxacin and penicillin. The present study provides data indicating a possible use of the seeds extract of A. cearensis in association with antibiotics in the fight against bacterial infections.

引用

页数：4

共 9 条

[1] Modulatory-antibiotic activity of the essential oil from Eucalyptus citriodora against MDR bacterial strains
Pinheiro, Raizza Eveline E.
Chaves, Thiago P.
Melo, Eveny S.
Ali, Sultan
Ali, Shinawar Waseem
Umer, Muhammad
Gama, Gil Sander P.
Lira, Dalliane N. S.
Souza, Joao Sammy N.
Soares, Maria Jose dos S.
Santos, Andre de Souza
Mota, Rinaldo Aparecido
Freitas, Priscilla Ramos
Afzal, Muhammad Inam
Salehi, Bahare
Coutinho, Henrique Douglas Melo
Setzer, William N.
Imran, Muhammad
Sharifi-Rad, Javad
CELLULAR AND MOLECULAR BIOLOGY, 2020, 66 (04) : 60 - 64
[2] Phytochemical composition, antibacterial and modulatory of antibiotic activity of the extract and fractions from Annona squamosa L.
Souza, Heloisa H. F.
Fernandes, Cicera N.
Tintino, Saulo R.
Morais-Braga, Maria Flaviana B.
Araujo, Antonia C.
Coutinho, Henrique D. M.
Menezes, Irwin R. A.
Kerntopf, Marta R.
ETHNOBIOLOGY AND CONSERVATION, 2013, 2
[3] Modulation of the Antibiotic Activity by Extracts from Amburana cearensis A. C. Smith and Anadenanthera macrocarpa (Benth.) Brenan
Figueredo, Fernando G.
Ferreira, Emerson O.
Lucena, Bruno F. F.
Torres, Cicero M. G.
Lucetti, Daniel L.
Lucetti, Elaine C. P.
Silva, Joao Marcos F. L.
Santos, Francisco A. V.
Medeiros, Cassio R.
Oliveira, Gardenia M. M.
Colares, Aracelio V.
Costa, Jose G. M.
Coutinho, Henrique D. M.
Menezes, Irwin R. A.
Silva, Julio C. F.
Kerntopf, Marta R.
Figueiredo, Patricia R. L.
Matias, Edinardo F. F.
BIOMED RESEARCH INTERNATIONAL, 2013, 2013
[4] Chemical composition and evaluation of modulatory of the antibiotic activity from extract and essential oil of Myracrodruon urundeuva
Figueredo, Fernando G.
Lucena, Bruno F. F.
Tintino, Saulo R.
Matias, Edinardo F. F.
Leite, Nadghia F.
Andrade, Jacqueline C.
Nogueira, Lavouisier F. B.
Morais, Edson C.
Costa, Jose G. M.
Coutinho, Henrique D. M.
Rodrigues, Fabiola F. G.
PHARMACEUTICAL BIOLOGY, 2014, 52 (05) : 560 - 565
[5] Polyphenol Content, Antioxidant Properties and Trypsin Inhibition Activity of Methanol Seed Extract and Fractions of White Velvet Bean from Vietnam
Ha, D. T.
Ha, P. T. T.
Tuyen, P. T.
Henry, R. J.
Loi, T. T.
Chi, T. N.
LEGUME RESEARCH, 2024, 47 (05) : 772 - 778
[6] Inhibition of the protease activity of the light chain of type A botulinum neurotoxin by aqueous extract from stinging nettle (Urtica dioica) leaf
Gul, N
Ahmed, SA
Smith, LA
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2004, 95 (05) : 215 - 219
[7] Serine Protease Inhibition Attenuates rIL-12-Induced GZMA Activity and Proinflammatory Events by Modulating the Th2 Profile From Estrogen-Treated Mice
Karpuzoglu, Ebru
Schmiedt, Chad W.
Pardo, Julian
Hansen, Megan
Guo, Tai L.
Holladay, Steven D.
Gogal, Robert M., Jr.
ENDOCRINOLOGY, 2014, 155 (08) : 2909 - 2923
[8] In vitro antibacterial and antibiotic modifying activity of crude extract, fractions and 3′, 4′, 7-trihydroxyflavone from Myristica fragrans Houtt against MDR Gram-negative enteric bacteria
Dzotam, Joachim K.
Simo, Ingrid Konga
Bitchagno, Gabin
Celik, Ilhami
Sandjo, Louis P.
Tane, Pierre
Kuete, Victor
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2018, 18
[9] In vitro antibacterial and antibiotic modifying activity of crude extract, fractions and 3′,4′,7-trihydroxyflavone from Myristica fragrans Houtt against MDR Gram-negative enteric bacteria
Joachim K. Dzotam
Ingrid Konga Simo
Gabin Bitchagno
Ilhami Celik
Louis P. Sandjo
Pierre Tane
Victor Kuete
BMC Complementary and Alternative Medicine, 18

← 1 →