Synthesis and Antimicrobial Activity of Tricyclic Quinazolinethiones

被引：6

作者：

Nasrullaev, A. O. ^{[1
]}

Islamova, Zh. I. ^{[1
]}

Elmuradov, B. Zh. ^{[1
]}

Bektemirov, A. M. ^{[2
]}

Osipova, S. O. ^{[1
]}

Khushbaktova, Z. A. ^{[1
]}

Syrov, V. N. ^{[1
]}

Shakhidoyatov, Kh. M. ^{[1
]}

机构：

[1] Acad Sci Uzbek, S Yu Yunusov Inst Chem Plant Subst, Tashkent, Uzbekistan

[2] Minist Publ Hlth Republ Uzbekistan, Res Inst Epidemiol Microbiol & Infect Dis, Tashkent, Uzbekistan

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2017年 / 51卷 / 05期

关键词：

Deoxyvasicine thione; mackinazoline thione; condensation with aldehydes; Vilsmeier-Haack reagent; nucleophilic substitution; 6-hydroxy-; -hydroseleno-; -chloro-; -anilinomethylidene derivatives; antimicrobial activity;

D O I：

10.1007/s11094-017-1614-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Deoxyvasicine thione (III) and mackinazoline thione (6,7,8,9-tetrahydro-11H-pyrido[2,1-b]quinazoline-11-thione, IV) were synthesized and condensed with aromatic and heterocyclic aldehydes at the alpha-methylene [CH2-3 (III) or CH2-6 (IV)]. Either 3- and 6-arylidene derivatives (V - XIII) or 6-hydroxymethylaryl derivatives (XIV) were formed depending on the reaction conditions. Formylation of IV synthesized the 6-hydroxymethylidene derivative (XV). 6-Chloro-, -hydroseleno-, and -anilinomethylidenemackinazoline thiones (XVI - XIX) were also synthesized. The antimicrobial activity of the synthesized compounds against S. aureus, E. coli, Bacillus cereus, Candida albicans, and Pseudomonas aeruginosa was studied.

引用

页码：355 / 360

页数：6

共 13 条

[1]

[Anonymous], 2012, CLSI M100-S22, V32

[2]

[Anonymous], 2012, M02A11 CLSI, V32

[3]

[Anonymous], 2004, MUK, V4, P1890

[4]

Elmuradov B. Zh., 2008, KHIM PRIR SOEDIN, P383

[5]

Elmuradov B. Zh, 2010, KHIM GETEROTSIKL, P1717

[6]

Ibragimov T. F., 2010, KHIM PRIR SOEDIN, P503

[7]

Nasrullaev A. O., 2011, KHIM KHIM TEKHNOL, P30

[8]

Nasrullaev A. O., 2012, KHIM PRIR SOEDIN, P573

[9]

Shakhidoyatov Kh. M, 1983, THESIS

[10]

Shakhidoyatov Kh. M, 2008, KHIM PRIR SOEDIN, P387

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