Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats

被引：4

作者：

Beczkowski, Pawel M. ^{[1
,2
]}

Techakriengkrai, Navapon ^{[1
]}

Logan, Nicola ^{[1
]}

McMonagle, Elizabeth ^{[1
]}

Litster, Annette ^{[3
]}

Willett, Brian J. ^{[1
]}

Hosie, Margaret J. ^{[1
]}

机构：

[1] Univ Glasgow, MRC, Ctr Virus Res, Glasgow, Lanark, Scotland

[2] Univ Glasgow, Small Anim Hosp, Glasgow, Lanark, Scotland

[3] Purdue Univ, Dept Vet Clin Sci, W Lafayette, IN 47907 USA

来源：

RETROVIROLOGY | 2014年 / 11卷

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

FIV; CD134; OX40; CRD2; Receptor; Evolution; Natural infection; Disease progression; RECEPTOR INTERACTION; FUNCTIONAL RECEPTOR; RANTES SENSITIVITY; T-CELLS; HIV-1; TYPE-1; CXCR4; AIDS; TROPISM; ENTRY;

D O I：

10.1186/s12977-014-0095-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection. Findings: Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression. Conclusions: These findings are consistent with a shift in CRD2 of CD134 usage with disease progression.

引用

页数：6

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