Emergence of CD134 cysteine-rich domain 2 (CRD2)-independent strains of feline immunodeficiency virus (FIV) is associated with disease progression in naturally infected cats

被引：4

作者：

Beczkowski, Pawel M. ^{[1
,2
]}

Techakriengkrai, Navapon ^{[1
]}

Logan, Nicola ^{[1
]}

McMonagle, Elizabeth ^{[1
]}

Litster, Annette ^{[3
]}

Willett, Brian J. ^{[1
]}

Hosie, Margaret J. ^{[1
]}

机构：

[1] Univ Glasgow, MRC, Ctr Virus Res, Glasgow, Lanark, Scotland

[2] Univ Glasgow, Small Anim Hosp, Glasgow, Lanark, Scotland

[3] Purdue Univ, Dept Vet Clin Sci, W Lafayette, IN 47907 USA

来源：

RETROVIROLOGY | 2014年 / 11卷

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

FIV; CD134; OX40; CRD2; Receptor; Evolution; Natural infection; Disease progression; RECEPTOR INTERACTION; FUNCTIONAL RECEPTOR; RANTES SENSITIVITY; T-CELLS; HIV-1; TYPE-1; CXCR4; AIDS; TROPISM; ENTRY;

D O I：

10.1186/s12977-014-0095-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: Feline immunodeficiency virus (FIV) infection is mediated by sequential interactions with CD134 and CXCR4. Field strains of virus vary in their dependence on cysteine-rich domain 2 (CRD2) of CD134 for infection. Findings: Here, we analyse the receptor usage of viral variants in the blood of 39 naturally infected cats, revealing that CRD2-dependent viral variants dominate in early infection, evolving towards CRD2-independence with disease progression. Conclusions: These findings are consistent with a shift in CRD2 of CD134 usage with disease progression.

引用

页数：6

共 36 条

[1] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1 [J].

Alkhatib, G ;

Combadiere, C ;

Broder, CC ;

Feng, Y ;

Kennedy, PE ;

Murphy, PM ;

Berger, EA .

SCIENCE, 1996, 272 (5270) :1955-1958

[2]

Beczkowski P M, 2013, THESIS U GLASGOW

[3] A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains [J].

Berson, JF ;

Long, D ;

Doranz, BJ ;

Rucker, J ;

Jirik, FR ;

Doms, RW .

JOURNAL OF VIROLOGY, 1996, 70 (09) :6288-6295

[4] The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes [J].

Bleul, CC ;

Wu, LJ ;

Hoxie, JA ;

Springer, TA ;

Mackay, CR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) :1925-1930

[5] A FELINE LARGE GRANULAR LYMPHOMA AND ITS DERIVED CELL-LINE [J].

CHENEY, CM ;

ROJKO, JL ;

KOCIBA, GJ ;

WELLMAN, ML ;

DIBARTOLA, SP ;

REZANKA, LJ ;

FORMAN, L ;

MATHES, LE .

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY, 1990, 26 (05) :455-463

[6] Change in coreceptor use correlates with disease progression in HIV-1-infected individuals [J].

Connor, RI ;

Sheridan, KE ;

Ceradini, D ;

Choe, S ;

Landau, NR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (04) :621-628

[7] THE CD4 (T4) ANTIGEN IS AN ESSENTIAL COMPONENT OF THE RECEPTOR FOR THE AIDS RETROVIRUS [J].

DALGLEISH, AG ;

BEVERLEY, PCL ;

CLAPHAM, PR ;

CRAWFORD, DH ;

GREAVES, MF ;

WEISS, RA .

NATURE, 1984, 312 (5996) :763-767

[8] Sequential CD134-CXCR4 interactions in feline immunodeficiency virus (FIV): Soluble CD134 activates FIV Env for CXCR4-dependent entry and reveals a cryptic neutralization epitope [J].

de Parseval, A ;

Grant, CK ;

Sastry, KJ ;

Elder, JH .

JOURNAL OF VIROLOGY, 2006, 80 (06) :3088-3091

[9] Feline immunodeficiency virus targets activated CD4+ T cells by using CD134 as a binding receptor [J].

de Parseval, A ;

Chatterji, U ;

Sun, PQ ;

Elder, JH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (35) :13044-13049

[10] Proviral burden and infection kinetics of feline immunodeficiency virus in lymphocyte subsets of blood and lymph node [J].

Dean, GA ;

Reubel, GH ;

Moore, PF ;

Pedersen, NC .

JOURNAL OF VIROLOGY, 1996, 70 (08) :5165-5169

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