Role of adipokines in obesity-associated hypertension

被引：47

作者：

Vlasova, M. ^{[2
]}

Purhonen, A. K. ^{[1
]}

Jarvelin, M. R. ^{[3
,4
,5
]}

Rodilla, E. ^{[6
]}

Pascual, J. ^{[6
]}

Herzig, K. H. ^{[1
,5
,7
]}

机构：

[1] Oulu Univ, Dept Physiol, Inst Biomed, Sch Med, Oulu 90014, Finland

[2] Univ Kuopio, Dept Pharmaceut, FIN-70211 Kuopio, Finland

[3] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England

[4] Natl Inst Hlth & Welf, Dept Lifecourse & Serv, Oulu, Finland

[5] Bioctr Oulu, Oulu, Finland

[6] Univ Valencia, Sagunto Hosp, Hypertens Clin, Valencia, Spain

[7] Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland

来源：

ACTA PHYSIOLOGICA | 2010年 / 200卷 / 02期

基金：

芬兰科学院;

关键词：

adipokines; cytokines; hypertension; inflammation; metabolic syndrome; obesity; TUMOR-NECROSIS-FACTOR; EPICARDIAL ADIPOSE-TISSUE; RENIN-ANGIOTENSIN SYSTEM; VASCULAR SMOOTH-MUSCLE; ENDOTHELIAL NITRIC-OXIDE; BODY-MASS INDEX; CARDIOVASCULAR RISK-FACTORS; SYMPATHETIC-NERVE ACTIVITY; APPARENTLY HEALTHY-MEN; PLASMA ADIPONECTIN CONCENTRATION;

D O I：

10.1111/j.1748-1716.2010.02171.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

It has been well documented that obesity is a major risk factor for the development of the hypertensive state. The correlation between body mass index and blood pressure level is well established. Nevertheless, the exact mechanisms which contribute to obesity-related hypertension remain poorly understood. In the last years, we have realized that the white adipose tissue is not just an inert organ for nutrient storage and isolation but rather depending on the body mass index the biggest endocrinological organ. Thus, the possible contribution of adipokines to the blood pressure elevation becomes an attractive hypothesis to explain the hypertensive state that often occurs in obesity. In this review, we consider direct and indirect effects of main adipokines on structural and functional changes in the cardiovascular system.

引用

页码：107 / 127

页数：21

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