Comparison of the Effects of Biofouling on Voltammetric and Potentiometric Measurements

被引：22

作者：

Kuhlmann, Julia ^{[1
]}

Dzugan, Laura C. ^{[2
]}

Heineman, William R. ^{[1
]}

机构：

[1] Univ Cincinnati, Dept Chem, Cincinnati, OH 45221 USA

[2] Samford Univ, Dept Chem & Biochem, Birmingham, AL 35229 USA

来源：

ELECTROANALYSIS | 2012年 / 24卷 / 08期

关键词：

Biofouling; Fibrinogen; Sensors; Potentiometry; Cyclic voltammetry; RELATIVELY HIGH SOLUBILITY; ELECTROCHEMICAL SENSORS; HUMAN FIBRINOGEN; BIOCOMPATIBILITY; ADSORPTION; BIOSENSORS;

D O I：

10.1002/elan.201200194

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Biofouling of sensors is a common problem when measuring biological samples. The adherence of proteins and biomolecules, called hemostasis, is the first of four steps that lead to biofouling and eventually a foreign body response. This typically occurs within the first hours after the exposure of the biosensor to a biological sample. The purpose of this study was to assess the effect of this initial step of biofouling on cyclic voltammetry and potentiometric measurements. The results show that biofouling occurred rapidly within minutes and strongly affected cyclic voltammetry measurements, while potentiometric measurements were minimally affected even after 24 hours.

引用

页码：1732 / 1738

页数：7

共 24 条

[1]

[Anonymous], 1996, REV EXPANDED

[2]

Bachmann R. T., 2005, Biofilms, V2, P197, DOI 10.1017/S1479050506001979

[3] Electrochemical sensors [J].

Bakker, E .

ANALYTICAL CHEMISTRY, 2004, 76 (12) :3285-3298

[4] Modern Potentiometry [J].

Bakker, Eric ;

Pretsch, Ernoe .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (30) :5660-5668

[5] Surveying for surfaces that resist the adsorption of proteins [J].

Chapman, RG ;

Ostuni, E ;

Takayama, S ;

Holmlin, RE ;

Yan, L ;

Whitesides, GM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (34) :8303-8304

[6] ELECTROANALYTICAL AND SURFACE CHARACTERIZATION OF ENCAPSULATED IMPLANTABLE MEMBRANE PLANAR MICROSENSORS [J].

COSOFRET, VV ;

ERDOSY, M ;

JOHNSON, TA ;

BELLINGER, DA ;

BUCK, RP ;

ASH, RB ;

NEUMAN, MR .

ANALYTICA CHIMICA ACTA, 1995, 314 (1-2) :1-11

[7] ELECTROCHEMICAL SENSORS FOR MONITORING ENVIRONMENTAL-POLLUTANTS [J].

FLEET, B ;

GUNASINGHAM, H .

TALANTA, 1992, 39 (11) :1449-1457

[8] In vivo biocompatibility and analytical performance of intravascular amperometric oxygen sensors prepared with improved nitric oxide-releasing silicone rubber coating [J].

Frost, MC ;

Rudich, SM ;

Zhang, HP ;

Maraschio, MA ;

Meyerhoff, ME .

ANALYTICAL CHEMISTRY, 2002, 74 (23) :5942-5947

[9] In vivo chemical sensors: Tackling biocompatibility [J].

Frost, Megan ;

Meyerhoff, Mark E. .

ANALYTICAL CHEMISTRY, 2006, 78 (21) :7370-7377

[10] Enhancing the blood compatibility of ion-selective electrodes [J].

Gavalas, VG ;

Berrocal, MJ ;

Bachas, LG .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2006, 384 (01) :65-72

← 1 2 3 →