One-Pot, Three-Component Synthesis of a Library of Spirooxindole-Pyrimidines Catalyzed by Magnetic Nanoparticle Supported Dodecyl Benzenesulfonic Acid in Aqueous Media

被引：106
作者：
Deng, Jia [1 ]
Mo, Li-Ping [1 ]
Zhao, Fei-Yang [1 ]
Zhang, Zhan-Hui [1 ]
Liu, Shou-Xin [2 ]
机构：
[1] Hebei Normal Univ, Coll Chem & Mat Sci, Key Lab Inorgan Nanomat Hebei Prov, Shijiazhuang 050024, Peoples R China
[2] Hebei Univ Sci & Technol, State Key Lab Breeding Base, Hebei Key Lab Mol Chem Drug, Shijiazhuang 050018, Peoples R China
来源：
ACS COMBINATORIAL SCIENCE | 2012年 / 14卷 / 05期
基金：
中国国家自然科学基金;
关键词：
one-pot synthesis; three-component reaction; spirooxindole-pyrimidine derivatives; functionalized silica-coated magnetic nanoparticles; EFFICIENT ONE-POT; FE3O4; NANOPARTICLES; SEPARABLE CATALYST; HIGHLY EFFICIENT; IONIC LIQUID; PALLADIUM; ALKYLATION; ARYLAMINES; SEPARATION; ALDEHYDES;
D O I：
10.1021/co3000264
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Dodecyl benzenesulfonic acid functionalized silica-coated magnetic nanoparticles (gamma-Fe2O3@SiO2-DDBSA) were readily prepared and identified as an efficient catalyst for the synthesis of a library of spirooxindole-pyrimidine derivatives by three-component condensation reaction of barbituric acids, isatins and cyclohexane-1,3-diones. The aqueous reaction medium, easy recovery of the catalyst using an external magnet, and high yields make the protocol sustainable and economic.
引用
收藏
页码：335 / 341
页数：7
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