Expression of hypoxia-inducible factor 1α gene affects the outcome in patients with ovarian cancer

被引:44
作者
Shimogai, R. [1 ]
Kigawa, J. [1 ]
Itamochi, H. [1 ]
Iba, T. [1 ]
Kanamori, Y. [1 ]
Oishi, T. [1 ]
Shimada, M. [1 ]
Sato, S. [1 ]
Kawaguchi, W. [1 ]
Sato, S. [1 ]
Terakawa, N. [1 ]
机构
[1] Tottori Univ, Sch Med, Dept Obstet & Gynecol, Yonago, Tottori 6838504, Japan
关键词
HIF-1; alpha; ovarian cancer; prognosis; VEGF;
D O I
10.1111/j.1525-1438.2007.01055.x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We conducted study to determine whether and how the expression of the hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene relates to outcome in patients with epithelial ovarian cancer. A total of 66 patients with epithelial ovarian cancer, who underwent primary surgery followed by platinum-based chemotherapy, were entered into this study. We confirmed the expression of HIF-1 alpha and the vascular endothelial growth factor (VEGF) by immunohistochemistry. To determine the quantity of HIF-1 alpha and VEGF expression, messenger RNA of each gene was measured by real-time reverse transcription-polymerase chain reaction. The cutoff values were determined by the receiver-operating characteristic curve according to survival. The protein expressions of HIF-1 alpha and VEGF were strongly observed in the cancer cells. The cutoff value of HIF-1 alpha and VEGF gene expression was 6.0 and 3.0, respectively. The expression of HIF-1 alpha did not relate to clinical stage, but tumor with low VEGF expression was observed more frequently in stage I patients. The response rate to chemotherapy did not differ between high and low expression of both genes. The overall survival for patients with high expression of HIF-1 alpha was significantly lower, but disease-free survival did not differ between high and low expression of HIF-1 alpha, whereas both overall and disease-free survival for patients with high expression of VEGF were significantly lower. Multivariate analysis revealed that FIGO stage and HIF-1 alpha expression were independent prognostic factors but that VEGF was not. The present study suggested that the expression level of HIF-1 alpha could be an independent prognostic factor in epithelial ovarian cancer.
引用
收藏
页码:499 / 505
页数:7
相关论文
共 32 条
[31]   VEGF and HIF-1α expression are increased in advanced stages of epithelial ovarian cancer [J].
Wong, C ;
Wellman, TL ;
Lounsbury, KM .
GYNECOLOGIC ONCOLOGY, 2003, 91 (03) :513-517
[32]   Prognostic impact of hypoxia-inducible factors 1α and 2α in colorectal cancer patients:: Correlation with tumor angiogenesis and cyclooxygenase-2 expression [J].
Yoshimura, H ;
Dhar, DK ;
Kohno, H ;
Kubota, H ;
Fujii, T ;
Ueda, S ;
Kinugasa, S ;
Tachibana, M ;
Nagasue, N .
CLINICAL CANCER RESEARCH, 2004, 10 (24) :8554-8560