MicroRNA-155 in oral squamous cell carcinoma: Overexpression, localization, and prognostic potential

被引：41
作者：
Shi, Lin-Jun [1 ]
Zhang, Chen-Yang [1 ]
Zhou, Zeng-Tong [1 ]
Ma, Jing-Yuan [1 ]
Liu, Yang [1 ]
Bao, Zhe-Xuan [1 ]
Jiang, Wei-Wen [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9,Shanghai Res Inst Stomato, Dept Oral Mucosal Dis,Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2015年 / 37卷 / 07期
基金：
中国国家自然科学基金;
关键词：
microRNA-155; oral squamous cell carcinoma; polymerase chain reaction (PCR); fluorescence in situ hybridization; prognosis; VIRUS-INDUCED LYMPHOMAS; LUNG-CANCER; EXPRESSION; MIR-155; HEAD; RNA; PROLIFERATION; CROSSTALK; PROFILES; INVASION;
D O I：
10.1002/hed.23700
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
BackgroundOral squamous cell carcinoma (OSCC) is a common malignancy with poor prognosis. MicroRNAs (miRNAs) play an important role in cancer, but their role in OSCC is not clarified. MethodsWe performed miRNA microarray, quantitative reverse transcription polymerase chain reaction (qRT-PCR), and fluorescence in situ hybridization (FISH) to examine miRNA expression in OSCC and paired adjacent cancer-free mucosal (ACF) tissues. ResultsThirteen miRNAs, including miRNA-155, were upregulated (>2-fold) in OSCC against ACF. MiRNA-155 was confirmed to have significantly higher expression in OSCC against ACF (paired-samples t test; p = .041) and it was localized in the cancer nest, inflammatory area, and vascular endothelium of OSCC. High expression of miRNA-155 in ACF tissue was an independent prognostic indicator for OSCC survival. ConclusionMiRNA-155 was overexpressed in OSCC and it was located in the cancer nest, inflammatory area, and vascular endothelium of OSCC. High miRNA-155 expression level in ACF may predict poor prognosis in patients with OSCC. (c) 2014 Wiley Periodicals, Inc. Head Neck 37: 970-976, 2015
引用
收藏
页码：970 / 976
页数：7
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