A Controlled-Release Drug Delivery System on a Chip Using Electrolysis

被引：19

作者：

Huang, Pen-Li ^{[1
,2
]}

Kuo, Po-Hung ^{[1
,2
]}

Huang, Yu-Jie ^{[1
,2
]}

Liao, Hsin-Hung ^{[3
]}

Yang, Yao-Joe Joseph ^{[3
]}

Wang, Tao ^{[4
]}

Wang, Yao-Hung ^{[5
]}

Lu, Shey-Shi ^{[1
,2
]}

机构：

[1] Natl Taiwan Univ, Grad Inst Elect Engn, Taipei 106, Taiwan

[2] Natl Taiwan Univ, Dept Elect Engn, Taipei 106, Taiwan

[3] Natl Taiwan Univ, Dept Mech Engn, Taipei 106, Taiwan

[4] Chang Gung Univ, Dept Elect Engn, Kwei Shan 333, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Med Imaging, Taipei 100, Taiwan

来源：

IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS | 2012年 / 59卷 / 03期

关键词：

Biomedical; CMOS integrated circuit (IC); drug delivery; system-on-a-chip; SUPER-REGENERATIVE RECEIVER; TRANSCEIVER; POLYMERS; ARRAY;

D O I：

10.1109/TIE.2011.2160135

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

A system-on-a-chip (SOC) with integrated drug reservoirs for drug delivery is proposed. Electrolysis is used to generate microbubbles, which are employed as a force to open the reservoirs and release the drug. Wireless components, including an on/off keying receiver, microcontrol unit, regulator, clock divider, and power-on reset, are integrated for remote drug activation. The proposed microchip is fabricated by Taiwan Semiconductor Manufacturing Company 0.35-mu m CMOS technology followed by post-IC processing. The total size is 2.48 mm(2), and the power consumption is 7.57 mW. The in vitro experiment has proven the feasibility of the proposed drug delivery SOC.

引用

页码：1578 / 1587

页数：10

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