Ruthenium-Catalyzed Hydrogen Evolution o-Aminoalkylation of Phenols with Cyclic Amines

被引：23

作者：

Cao, Liang ^{[1
]}

Zhao, He ^{[1
]}

Tan, Zhenda ^{[1
]}

Guan, Rongqing ^{[1
]}

Jiang, Huanfeng ^{[1
]}

Zhang, Min ^{[1
]}

机构：

[1] South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Sch Chem & Chem Engn, Guangzhou 510641, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 12期

基金：

中国国家自然科学基金;

关键词：

DIRECT ACCESS; FUNCTIONALIZATION; CYCLIZATION; BONDS; DEHYDROGENATION; ALKYLATION; ALCOHOLS; ALKENES;

D O I：

10.1021/acs.orglett.0c01580

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we present a ruthenium-catalyzed new hydrogen evolution ortho-aminoalkylation of phenolic derivatives with cyclic amines as the coupling agents. The developed cross-coupling reaction offers a practical platform for direct access to a variety of functionalized phenols with the features of good substrate and functional group compatibility, readily available catalyst system and feedstocks, no need for additional sacrificial oxidants, and high atom efficiency.

引用

页码：4781 / 4785

页数：5

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