Metal-Free C-H Cross-Coupling toward Oxygenated Naphthalene-Benzene Linked Biaryls

被引：80

作者：

Dohi, Toshifumi ^{[1
]}

Ito, Motoki ^{[1
,2
]}

Itani, Itsuki ^{[1
]}

Yamaoka, Nobutaka ^{[1
]}

Morimoto, Koji ^{[1
]}

Fujioka, Hiromichi ^{[2
]}

Kita, Yasuyuki ^{[1
]}

机构：

[1] Ritsumeikan Univ, Coll Pharmaceut Sci, Kusatsu, Shiga 5258577, Japan

[2] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 23期

基金：

日本学术振兴会;

关键词：

PHENOL ETHER DERIVATIVES; HYPERVALENT IODINE(III) REAGENT; CATALYZED ORTHO-ARYLATION; NUCLEOPHILIC-SUBSTITUTION; PHENANTHROVIRIDIN AGLYCON; REMOTE-METALATION; ORGANIC-SYNTHESIS; BOND FORMATION; SIMPLE ARENES; ANTIBIOTICS;

D O I：

10.1021/ol202632h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The intermolecular C-H cross-coupling between aromatic ethers has been achieved for the first time using perfluorinated hypervalent iodine(III) compounds as extreme single-electron-transfer (SET) oxidants. The demonstrations of this specific coupling could provide a direct route to valuable oxygenated mixed naphthalene-benzene biaryls 3 only, without formation of other biaryl-derived byproducts.

引用

页码：6208 / 6211

页数：4

共 64 条

[1] Synthetic studies on jadomycins: synthesis of dimethyljadomycin A [J].