Coexistent Rearrangements of c-MYC, BCL2, and BCL6 genes in a diffuse large B-cell lymphoma

被引：20

作者：

Ueda, C ^{[1
]}

Nishikori, M ^{[1
]}

Kitawaki, T ^{[1
]}

Uchiyama, T ^{[1
]}

Ohno, H ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Hematol & Oncol, Sakyo Ku, Kyoto 6068507, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2004年 / 79卷 / 01期

关键词：

diffuse large B-cell lymphoma; c-MYC; BCL2; BCL6; long-distance PCR;

D O I：

10.1007/BF02983534

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We present a patient with stage III de novo diffuse large B-cell lymphoma. The lymphoma cells showed mature B-cell immunophenotype but lacked surface immunoglobulin (Ig) expression. Long-distance and long-distance inverse polymerase chain reaction assays to detect the oncogene/Ig gene rearrangement revealed that the cells carried 3 independent fusion genes, namely, c-MYC/Ig heavy chain gene (IgH), BCL2/IgH, and Ig lambda light chain gene/BCL6. Thus, the lymphoma cells concurrently carried t(8;14)(q24;q32), t(14;18)(q32;q21), and t(3;22)(q27;q11), which developed in association with class switching, V/D/J recombination, and somatic hypermutation, respectively. The lymphoma responded to chemoradiotherapy, and the patient has been well for 2 years, suggesting that multiple oncogene rearrangements may not necessarily be associated with poor clinical outcome. (C) 2004 The Japanese Society of Hematology.

引用

页码：52 / 54

页数：3

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