Alike but Different: RAF Paralogs and Their Signaling Outputs

被引：88

作者：

Desideri, Enrico ^{[1
]}

Cavallo, Anna Lina ^{[1
]}

Baccarini, Manuela ^{[1
]}

机构：

[1] Univ Vienna, Ctr Mol Biol, Dept Microbiol Immunol & Genet, Max F Perutz Labs, A-1030 Vienna, Austria

来源：

CELL | 2015年 / 161卷 / 05期

关键词：

ARAF MUTATIONS; B-RAF; C-RAF; CANCER; BRAF; INHIBITORS; MELANOMA; SCAFFOLD; KINASES; ROLES;

D O I：

10.1016/j.cell.2015.04.045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RAF links RAS, one of the most potent human oncogenes, to its effector ERK and to proliferation. This role is evolutionarily conserved, but while simpler multicellular organisms express one RAF, mammals have three. This Minireview highlights common and divergent features of RAF paralogs, their signaling outputs, and roles in tumorigenesis.

引用

页码：967 / 970

页数：4

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