Expression of microRNA-331 can be used as a predictor for response to therapy and survival in acute myeloid leukemia patients

被引：32

作者：

Butrym, Aleksandra ^{[1
,2
]}

Rybka, Justyna ^{[1
]}

Baczynska, Dagmara ^{[3
]}

Tukiendorf, Andrzej ^{[4
]}

Kuliczkowski, Kazimierz ^{[1
]}

Mazur, Grzegorz ^{[5
]}

机构：

[1] Wroclaw Med Univ, Dept Hematol Blood Neoplasms & Bone Marrow Transp, PL-50367 Wroclaw, Poland

[2] Wroclaw Med Univ, Dept Physiol, PL-50368 Wroclaw, Poland

[3] Wroclaw Med Univ, Mol Tech Unit, Dept Forens Med, PL-50369 Wroclaw, Poland

[4] Inst Oncol, Canc Ctr, Dept Epidemiol, PL-44101 Gliwice, Poland

[5] Wroclaw Med Univ, Dept Internal & Occupat Dis & Hypertens, PL-50556 Wroclaw, Poland

来源：

BIOMARKERS IN MEDICINE | 2015年 / 9卷 / 05期

关键词：

acute myeloid leukemia; expression; miR-331; prognosis; survival; MIR-331-3P; TARGETS;

D O I：

10.2217/bmm.14.112

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: Aberrant expression of microRNAs (miRs) has been proved to have a role in acute myeloid leukemias (AML), but there is no information on miR-331 in AML. Materials & methods: miR-331 expression has been analyzed using reverse-transcription polymerase chain reaction (RT-PCR) in 95 bone marrow specimens from newly diagnosed AML patients in comparison with 20 healthy subjects. Results: miR-331 was upregulated in AML patients and its expression seemed to influence remission achieving and death risk. The time of remission duration in patients with complete remission was longer in subjects with miR-331 downregulation after induction chemotherapy. Conclusion: we showed for the first time that miR-331 higher expression appears to be correlated with worse response to therapy and shorter survival of AML patients.

引用

页码：453 / 460

页数：8

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