Nanocomposite Hydrogels: 3D Polymer-Nanoparticle Synergies for On-Demand Drug Delivery

被引：665

作者：

Merino, Sonia ^{[1
]}

Martin, Cristina ^{[1
]}

Kostarelos, Kostas ^{[2
,3
]}

Prato, Maurizio ^{[4
]}

Vazquez, Ester ^{[1
]}

机构：

[1] Univ Castilla La Mancha, Dept Quim Organ, Fac Ciencias & Tecnol Quim IRICA, E-13071 Ciudad Real, Spain

[2] Univ Manchester, Fac Med & Human Sci, Nanomed Lab, Manchester M13 9PT, Lancs, England

[3] Univ Manchester, Natl Graphene Inst, Manchester M13 9PT, Lancs, England

[4] Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy

来源：

ACS NANO | 2015年 / 9卷 / 05期

基金：

英国工程与自然科学研究理事会;

关键词：

hydrogel; nanoparticle; nanocomposite; nanogel; self-healing; on-demand delivery; stimuli-response external field; CONTROLLED-RELEASE; CARBON NANOTUBE; TRIGGERED RELEASE; HYBRID HYDROGEL; GRAPHENE; SYSTEMS; BEHAVIOR; GELS; CHALLENGES; PROGRESS;

D O I：

10.1021/acsnano.5b01433

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Considerable progress in the synthesis and technology of hydrogels makes these materials attractive structures for designing controlled-release drug delivery systems. In particular, this review highlights the latest advances in nanocomposite hydrogels as drug delivery vehicles. The inclusion/incorporation of nanoparticles in three-dimensional polymeric structures is an innovative means for obtaining multicomponent systems with diverse functionality within a hybrid hydrogel network. Nanoparticle-hydrogel combinations add synergistic benefits to the new 3D structures. Nanogels as carriers for cancer therapy and injectable gels with improved self-healing properties have also been described as new nanocomposite systems.

引用

页码：4686 / 4697

页数：12

共 72 条

[1] pH-sensitive nanogels based on Boltorn® H40 and poly(vinylpyridine) using mini-emulsion polymerization for delivery of hydrophobic anticancer drugs [J].