Synthesis of biologically active biheterocyclc oxadiazolyl benzofurans and other derivatives of benzofuran

被引：0

作者：

Basavaraja, KM ^{[1
]}

Agasimundin, YS

Mahadevan, KM

Vaidya, VP

机构：

[1] Gulbarga Univ, PG Ctr, Dept Chem, Bellary 583104, India

[2] Kuvempu Univ, Dept Chem, Shankaraghatta 577451, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2003年 / 13卷 / 02期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various 5'-substituted-3-methoxy-[(1,3',4-oxadiazol-2'-yl)]-benzofurans have been synthesized by different routes by using 3-methoxybenzofuran-2-carboxyhydrazide 2 as an intermediate. The carboxyhdrazide 2 on refluxing with various isothiocyanates produced carbothiosemicarbazides (3a-f), which have been subjected to oxidative cyclization to obtain oxadiazoles (4a-f). In an another route compound 2 has been refluxed with different carboxylic acids in presence of POCl3 to obtain corresponding oxadiazoles (7a-c). Reaction of 2 with appropriate aldehydes and ketones leads to the formation of corresponding hydrazones (11a-m). All the synthesized compounds have been characterized by spectral data and screened for antibacterial and some selected compounds for antiinflammatory activity.

引用

页码：155 / 158

页数：4

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