Nivolumab in the treatment of metastatic squamous non-small cell lung cancer: a review of the evidence

被引：24

作者：

Lim, Joline S. J. ^{[2
]}

Soo, Ross A. ^{[1
]}

机构：

[1] Natl Univ Hlth Syst, Natl Univ Canc Inst, Dept Haematol Oncol, 1E Kent Ridge Rd,NUHS Tower Block Level 7, Singapore 119228, Singapore

[2] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore, Singapore

来源：

THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE | 2016年 / 10卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

anti-programmed death-1; immunotherapy; nivolumab; non-small cell lung cancer; ANTI-PD-1; ANTIBODY; PD-L1; EXPRESSION; CHECKMATE; 063; NSCLC; DOCETAXEL; SAFETY; TRIAL; BMS-936558; ONO-4538; CHEMOTHERAPY;

D O I：

10.1177/1753465816661091

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Progress in the treatment of patients with advanced stage squamous cell non-small cell lung cancer (NSCLC) has been limited. An improvement in the understanding of tumor immunosurveillance has resulted in the development of the immune checkpoint inhibitors such as nivolumab. Nivolumab (Opdivo((R))), a human immunoglobulin (Ig)G4 anti-programmed death (PD)-1 monoclonal antibody, was the first PD-1 inhibitor approved in the treatment of patients with advanced stage squamous cell NSCLC following platinum-based chemotherapy. CHECKMATE 017, a randomized phase III study of second-line nivolumab versus docetaxel, significantly improved overall survival (OS), progression-free survival (PFS), patient reported outcomes and the safety and tolerability favored patients treated with nivolumab. The ligand (PD-L1) expression did not predict for outcome. In this paper, we review the role of nivolumab in the treatment of NSCLC with particular attention on recent studies, ongoing combination studies, toxicity profile, current and potential predictive biomarkers.

引用

页码：444 / 454

页数：11

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