Prostate-Specific Membrane Antigen-Targeted Imaging With [18F] DCFPyL in High-Grade Gliomas

被引：50

作者：

Fragomeni, Roberto Andres Salas ^{[1
]}

Menke, Joshua R. ^{[2
]}

Holdhoff, Matthias ^{[3
]}

Ferrigno, Clare ^{[3
]}

Laterra, John Joseph ^{[3
]}

Solnes, Lilja B. ^{[1
]}

Javadi, Mehrbod S. ^{[1
]}

Szabo, Zsolt ^{[1
]}

Pomper, Martin G. ^{[1
,3
]}

Rowe, Steven P. ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA

[2] Johns Hopkins Sch Med, Dept Pathol, Baltimore, MD 21287 USA

[3] Johns Hopkins Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21287 USA

来源：

CLINICAL NUCLEAR MEDICINE | 2017年 / 42卷 / 10期

关键词：

glioblastoma; gliomas; MRI; PET/CT; primary brain tumor; prostate-specific membrane antigen; PSMA; EXPRESSION;

D O I：

10.1097/RLU.0000000000001769

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

High-grade gliomas (World Health Organization grade III-IV) are highly lethal primary brain tumors. Imaging modalities, including MRI and FDG PET, provide a limited ability to differentiate treatment effects (such as radiation necrosis) from recurrent or residual tumor. As the first step in validating the applicability of prostate-specific membrane antigen (PSMA)-targeted imaging in high-grade gliomas, we evaluated the ability of the PSMA-targeted small molecule [F]DCFPyL (2-(3-(1carboxy-5-(6-[F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentanedioic acid) to image high-grade gliomas in a series of 3 prospectively recruited patients. We found [F]DCFPyL binds PSMA in the neovasculature of glioblastoma multiforme and tumor cells of anaplastic astrocytoma.

引用

页码：E433 / E435

页数：3

共 8 条

[1]

Chang SS, 1999, CANCER RES, V59, P3192

[2] 2-(3-{1-Carboxy-5-[(6-[18F]Fluoro-Pyridine-3-Carbonyl)-Amino]-Pentyl}-Ureido)-Pentanedioic Acid, [18F]DCFPyL, a PSMA-Based PET Imaging Agent for Prostate Cancer [J].

Chen, Ying ;

Pullambhatla, Mrudula ;

Foss, Catherine A. ;

Byun, Youngjoo ;

Nimmagadda, Sridhar ;

Senthamizhchelvan, Srinivasan ;

Sgouros, George ;

Mease, Ronnie C. ;

Pomper, Martin G. .

CLINICAL CANCER RESEARCH, 2011, 17 (24) :7645-7653

[3] Prostate-specific membrane antigen (PSMA) protein expression in normal and neoplastic tissues and its sensitivity and specificity in prostate adenocarcinoma: an immunohistochemical study using mutiple tumour tissue microarray technique [J].

Mhawech-Fauceglia, P. ;

Zhang, S. ;

Terracciano, L. ;

Sauter, G. ;

Chadhuri, A. ;

Herrmann, F. R. ;

Penetrante, R. .

HISTOPATHOLOGY, 2007, 50 (04) :472-483

[4] Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases [J].

Nomura, Natsuko ;

Pastorino, Sandra ;

Jiang, Pengfei ;

Lambert, Gage ;

Crawford, John R. ;

Gymnopoulos, Marco ;

Piccioni, David ;

Juarez, Tiffany ;

Pingle, Sandeep C. ;

Makale, Milan ;

Kesari, Santosh .

CANCER CELL INTERNATIONAL, 2014, 14

[5] Diagnostic Value of 68Ga PSMA-11 PET/CT Imaging of Brain Tumors-Preliminary Analysis [J].

Sasikumar, Arun ;

Joy, Ajith ;

Pillai, M. R. A. ;

Nanabala, Raviteja ;

Anees, Muhammed K. ;

Jayaprakash, P. G. ;

Madhavan, Jayaprakash ;

Nair, Suresh .

CLINICAL NUCLEAR MEDICINE, 2017, 42 (01) :E41-E48

[6] In vivo visualization of prostate-specific membrane antigen in glioblastoma [J].

Schwenck, Johannes ;

Tabatabai, Ghazaleh ;

Skardelly, Marco ;

Reischl, Gerhald ;

Beschorner, Rudi ;

Pichler, Bernd ;

la Fougere, Christian .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2015, 42 (01) :170-171

[7] Initial Evaluation of [18F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer [J].

Szabo, Zsolt ;

Mena, Esther ;

Rowe, Steven P. ;

Plyku, Donika ;

Nidal, Rosa ;

Eisenberger, Mario A. ;

Antonarakis, Emmanuel S. ;

Fan, Hong ;

Dannals, Robert F. ;

Chen, Ying ;

Mease, Ronnie C. ;

Vranesic, Melin ;

Bhatnagar, Akrita ;

Sgouros, George ;

Cho, Steve Y. ;

Pomper, Martin G. .

MOLECULAR IMAGING AND BIOLOGY, 2015, 17 (04) :565-574

[8] Prostate-Specific Membrane Antigen as a Potential Novel Vascular Target for Treatment of Glioblastoma Multiforme [J].

Wernicke, A. Gabriella ;

Edgar, Mark A. ;

Lavi, Ehud ;

Liu, He ;

Salerno, Pamela ;

Bander, Neil H. ;

Gutin, Philip H. .

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2011, 135 (11) :1486-1489

← 1 →