Pharmacogenomics and personalized medicine in clinical practice

被引:1
作者
Manolopoulos, Vangelis G. [2 ]
Dechairo, Bryan [3 ]
Huriez, Alain [4 ]
Kuehn, Alexander [5 ]
LLerena, Adrian [6 ]
van Schaik, Ron H. [7 ]
Yeo, Kiang-Teck J. [8 ]
Ragia, Georgia [2 ]
Siest, Gerard [1 ]
机构
[1] Univ Henri Poincare, Nancy, France
[2] Democritus Univ Thrace, Sch Med, Alexandroupolis, Greece
[3] Medco Hlth Solut Inc, Bethesda, MD USA
[4] EPEMED, Nantes, France
[5] Max Planck Inst Mol Genet, Berlin, Germany
[6] Extremadura Univ Hosp & Med Sch, Clin Res Ctr, Badajoz, Spain
[7] Erasmus MC, Dept Clin Chem, Rotterdam, Netherlands
[8] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA
关键词
biomarkers; cytochromes; personalized medicine; pharmacogenetics; pharmacogenomics; theranostics; POLYMORPHISMS; TRIAL;
D O I
10.2217/PGS.11.14
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The Santorini Conference on prospective biology, genomics and pharmacogenomics occurs every 2 years. On 30 September to 2nd October 2010, the fifth meeting in this series took place in Santorini, Greece. This conference has established a tradition of organizing a workshop each time to address the most recent developments and key issues in pharmacogenomics. This year, the workshop was chaired by Bryan Dechairo and Alain Huriez, and was titled 'Pharmacogenomics and personalized medicine in clinical practice'.
引用
收藏
页码:597 / 610
页数:14
相关论文
共 9 条
[1]   Warfarin Genotyping Reduces Hospitalization Rates Results From the MM-WES (Medco-Mayo Warfarin Effectiveness Study) [J].
Epstein, Robert S. ;
Moyer, Thomas P. ;
Aubert, Ronald E. ;
O'Kane, Dennis J. ;
Xia, Fang ;
Verbrugge, Robert R. ;
Gage, Brian F. ;
Teagarden, J. Russell .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (25) :2804-2812
[2]   The hallmarks of cancer [J].
Hanahan, D ;
Weinberg, RA .
CELL, 2000, 100 (01) :57-70
[3]   Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials [J].
Iakoubova, Olga A. ;
Tong, Carmen H. ;
Rowland, Charles M. ;
Kirchgessner, Todd G. ;
Young, Bradford A. ;
Arellano, Andre R. ;
Shiffman, Dov ;
Sabatine, Marc S. ;
Campos, Hannia ;
Packard, Christopher J. ;
Pfeffer, Marc A. ;
White, Thomas J. ;
Braunwald, Eugene ;
Shepherd, James ;
Devlin, James J. ;
Sacks, Frank M. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (04) :435-443
[4]   Cytochrome P-450 Polymorphisms and Response to Clopidogrel. [J].
Mega, Jessica L. ;
Close, Sandra L. ;
Wiviott, Stephen D. ;
Shen, Lei ;
Hockett, Richard D. ;
Brandt, John T. ;
Walker, Joseph R. ;
Antman, Elliott M. ;
Macias, William ;
Braunwald, Eugene ;
Sabatine, Marc S. .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (04) :354-362
[5]   Optimization of Initial Tacrolimus Dose Using Pharmacogenetic Testing [J].
Thervet, E. ;
Loriot, M. A. ;
Barbier, S. ;
Buchler, M. ;
Ficheux, M. ;
Choukroun, G. ;
Toupance, O. ;
Touchard, G. ;
Alberti, C. ;
Le Pogamp, P. ;
Moulin, B. ;
Le Meur, Y. ;
Heng, A. E. ;
Subra, J. F. ;
Beaune, P. ;
Legendre, C. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2010, 87 (06) :721-726
[6]   Comparing Mycophenolate Mofetil Regimens for de Novo Renal Transplant Recipients: The Fixed-Dose Concentration-Controlled Trial [J].
van Gelder, Tenn ;
Silva, Helio Tedesco ;
de Fijter, Johan W. ;
Budde, Klemens ;
Kuypers, Dirk ;
Tyden, Gunnar ;
Lohmus, Aleksander ;
Sommerer, Claudia ;
Hartmann, Anders ;
Le Meur, Yann ;
Oellerich, Michael ;
Holt, David W. ;
Toenshoff, Burkhard ;
Keown, Paul ;
Campbell, Scott ;
Mamelok, Richard D. .
TRANSPLANTATION, 2008, 86 (08) :1043-1051
[7]   UGT1A9-275T>A/-2152C>T Polymorphisms Correlate With Low MPA Exposure and Acute Rejection in MMF/Tacrolimus-Treated Kidney Transplant Patients [J].
van Schaik, R. H. N. ;
van Agteren, M. ;
de Fijter, J. W. ;
Hartmann, A. ;
Schmidt, J. ;
Budde, K. ;
Kuypers, D. ;
Le Meur, Y. ;
van der Werf, M. ;
Mamelok, R. ;
van Gelder, T. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2009, 86 (03) :319-327
[8]  
van Schie RMF, 2009, PHARMACOGENOMICS, V10, P1687, DOI [10.2217/pgs.09.125, 10.2217/PGS.09.125]
[9]  
Wierling Christoph, 2007, Briefings in Functional Genomics & Proteomics, V6, P240, DOI 10.1093/bfgp/elm027