Expression of HGF and cMet in the peripheral nervous system of adult rats following sciatic nerve injury

被引：60
作者：
Hashimoto, N
Yamanaka, H
Fukuoka, T
Dai, Y
Obata, K
Mashimo, T
Noguchi, K
机构：
[1] Hyogo Coll Med, Dept Anat & Neurosci, Nishinomiya, Hyogo 6638501, Japan
[2] Osaka Univ, Sch Med, Dept Anesthesiol & Acute Crit Med, Suita, Osaka 5650871, Japan
来源：
NEUROREPORT | 2001年 / 12卷 / 07期
关键词：
cMet; hepatocyte growth factor; nerve injury; Schwann cell;
D O I：
10.1097/00001756-200105250-00022
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Hepatocyte growth factor (HGF) exhibits neurotrophic properties on different types of neuron, including motor, sensory and parasympathetic neurons. We demonstrate that sciatic nerve ligation induces an increase of the HGF receptor, c-met, mRNA in the distal segment of the sciatic nerve to the ligation site and a delayed elevation in the proximal segment. Immunohistochemical analysis revealed co-localization of cMet and GFAP and indicates that Schwann cells express cMet in the sciatic nerve after injury: HGF mRNA was detected in the spinal cord and DRG, and nerve injury did not alter the expression. These data demonstrate that the expression of HGF and cMet in the peripheral nervous system shows the unique pattern of regulation following nerve injury. NeuroReport 12:1403-1407 (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码：1403 / 1407
页数：5
相关论文
共 50 条
[21]   Controlled Trial of Efficacy of Dexketoprofen in Sciatic Nerve Crush Injury in Rats [J].
Kaptan, Hulagu ;
Kasimcan, Omur ;
Ayaz, Murat ;
Bozdogan, Onder ;
Karabagli, Hakan .
JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, 2014, 31 (01) :126-135
[22]   Treadmill running promotes functional recovery and decreases brain-derived neurotrophic factor mRNA expression following sciatic crushed nerve injury in rats [J].
Byun, YH ;
Lee, MH ;
Kim, SS ;
Kim, H ;
Chang, HK ;
Lee, TH ;
Jang, MH ;
Shin, MC ;
Shin, MS ;
Kim, CJ .
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS, 2005, 45 (02) :222-228
[23]   BDNF is involved in sympathetic sprouting in the dorsal root ganglia following peripheral nerve injury in rats [J].
Yan-Shen Deng ;
Jin-Hua Zhong ;
Xin-Fu Zhou .
Neurotoxicity Research, 1999, 1 :311-322
[24]   BDNF is involved in sympathetic sprouting in the dorsal root ganglia following peripheral nerve injury in rats [J].
Deng, Yan-Shen ;
Zhong, Jin-Hua ;
Zhou, Xin-Fu .
NEUROTOXICITY RESEARCH, 1999, 1 (04) :311-322
[25]   Analysis of Schwann Cell Migration and Axon Regeneration Following Nerve Injury in the Sciatic Nerve Bridge [J].
Chen, Bing ;
Chen, Quan ;
Parkinson, David B. ;
Dun, Xin-peng .
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2019, 12
[26]   Expression of HGF and VEGF in the cerebral tissue of adult rats with chronic hydrocephalus after subarachnoid hemorrhage [J].
Chu, Sheng-Hua ;
Feng, Dong-Fu ;
Ma, Yan-Bin ;
Zhang, Hong ;
Zhu, Zhi-An ;
Li, Zhi-Qiang ;
Zhang, Zi-Heng .
MOLECULAR MEDICINE REPORTS, 2011, 4 (05) :785-791
[27]   SUBCELLULAR LOCALIZATION OF RYANODINE RECEPTOR ISOFORM MRNAS IN NORMAL RAT SCIATIC NERVE AND EXPRESSION OF THESE ISOFORMS DURING SCIATIC NERVE INJURY [J].
Dent, M. ;
Martinez-Gomez, A. .
GLIA, 2011, 59 :S66-S66
[28]   NOVEL DISTRIBUTION OF CLUSTER OF DIFFERENTIATION 200 ADHESION MOLECULE IN GLIAL CELLS OF THE PERIPHERAL NERVOUS SYSTEM OF RATS AND ITS MODULATION AFTER NERVE INJURY [J].
Chang, C. -Y. ;
Lee, Y. -H. ;
Jiang-Shieh, Y. -F. ;
Chien, H. -F. ;
Pai, M. -H. ;
Chen, H. -M. ;
Fong, T. -H. ;
Wu, C. -H. .
NEUROSCIENCE, 2011, 183 :32-46
[29]   Effects of trimetazidine on crush injury of the sciatic nerve in rats: A biochemical and stereological study [J].
Serayslan, Yurdal ;
Bal, Ramazan ;
Altug, Muhammed Enes ;
Kontas, Tuenay ;
Keles, Osman Nuri ;
Unal, Deniz ;
Unal, Bunyami .
BRAIN RESEARCH, 2009, 1247 :11-20
[30]   Immunological Demyelination Enhances Nerve Regeneration After Acute Transection Injury in the Adult Rat Sciatic Nerve [J].
Kosins, Aaron M. ;
Scholz, Thomas ;
Lin, Michael ;
Evans, Gregory R. D. ;
Keirstead, Hans S. .
ANNALS OF PLASTIC SURGERY, 2012, 68 (03) :290-294
12345