An evaluation of the reinforcing effects of memantine in cocaine-dependent humans

被引：20
作者：
Vosburg, SK [1 ]
Hart, CL [1 ]
Haney, M [1 ]
Foltin, RW [1 ]
机构：
[1] Columbia Univ, Coll Phys & Surg, New York State Psychiat Inst, Dept Subst Abuse, New York, NY 10032 USA
来源：
DRUG AND ALCOHOL DEPENDENCE | 2005年 / 79卷 / 02期
关键词：
NMDA antagonists; memantine; self-administration; cocaine; adults;
D O I：
10.1016/j.drugalcdep.2005.01.020
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
The purpose of this double-blind, outpatient study was to evaluate the reinforcing and subjective effects of the uncompetitive N-methyl-D-aspartate (NMDA) antagonist memantine in cocaine-dependent humans. Eight participants (two females, six males) completed this study which consisted of three blocks of seven sessions; each block tested a different dose of memantine. During the first two sessions of each block, participants "sampled" the memantine capsule (10, 20, or 30 mg) and the placebo capsule that were available for the next five sessions. During the five subsequent sessions, participants had an opportunity to self-administer either the active or placebo capsule. Memantine was not reinforcing and subjective-effects ratings were not altered as a function of dose. Results suggest that these doses of memantine do not have abuse liability in cocaine-dependent individuals. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：257 / 260
页数：4
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