NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION

被引：11

作者：

Wardakhan, Wagnat Wahba ^{[1
]}

Samir, Ewan Mohamed ^{[1
]}

机构：

[1] Natl Org Drug Control & Res NODCAR, Cairo, Egypt

来源：

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY | 2012年 / 57卷 / 02期

关键词：

hydrazide-hydrazone; pyridazine; 1,2,3-triazole; pyrazole; anti-tumor; ANTITUBERCULOTIC ACTIVITY; ANTICONVULSANT ACTIVITY; 4-THIAZOLIDINONES; SEMICARBAZONES; AGENTS; ACID;

D O I：

10.4067/S0717-97072012000200013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The hydrazide-hydrazone 3 reacted with benzenediazonium chloride to give the phenylhydrazone derivative 5. The latter underwent a series of heterocyclization reactions to give pyridazine, 1,2,3-triazole and pyrazole derivatives. The antitumor evaluation of the newly synthesized products against the three cancer cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCl-H460) and CNS cancer (SF-268) showed that some of them have higher inhibitory effects towards the three cell lines compared to the standard.

引用

页码：1118 / 1121

页数：4

共 19 条

[11]

Kuc S. G., 1999, EUR J MED CHEM, V34, P1093

[12] Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds [J].

Küçükgüzel, SG ;

Oruç, EE ;

Rollas, S ;

Sahin, F ;

Özbek, A .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2002, 37 (03) :197-206

[13]

Pandeya SN, 2001, PHARMAZIE, V56, P121

[14]

PATEL JM, 1984, J INDIAN CHEM SOC, V61, P718

[15] Synthesis and antimicrobial activity of some new hydrazones of 4-fluorobenzoic acid hydrazide and 3-acetyl-2,5-disubstituted-1,3,4-oxadiazolines [J].

Rollas, S ;

Gulerman, N ;

Erdeniz, H .

FARMACO, 2002, 57 (02) :171-174

[16] ANTIMICROBIALS - NEW NITROFURAN DERIVATIVES [J].

SZARVASI, E ;

FONTAINE, L ;

BETBEDER.A .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (03) :281-287

[17]

Ulusoy N, 2001, Boll Chim Farm, V140, P417

[18]

Ulusoy N, 2000, Boll Chim Farm, V139, P167

[19] Synthesis and anticonvulsant activity of some new arylidenehydrazides and 4-thiazolidinones [J].

Ulusoy, N ;

Ergenc, N ;

Ekinci, AC ;

Ozer, H .

MONATSHEFTE FUR CHEMIE, 1996, 127 (11) :1197-1202

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