NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION

被引：11

作者：

Wardakhan, Wagnat Wahba ^{[1
]}

Samir, Ewan Mohamed ^{[1
]}

机构：

[1] Natl Org Drug Control & Res NODCAR, Cairo, Egypt

来源：

JOURNAL OF THE CHILEAN CHEMICAL SOCIETY | 2012年 / 57卷 / 02期

关键词：

hydrazide-hydrazone; pyridazine; 1,2,3-triazole; pyrazole; anti-tumor; ANTITUBERCULOTIC ACTIVITY; ANTICONVULSANT ACTIVITY; 4-THIAZOLIDINONES; SEMICARBAZONES; AGENTS; ACID;

D O I：

10.4067/S0717-97072012000200013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The hydrazide-hydrazone 3 reacted with benzenediazonium chloride to give the phenylhydrazone derivative 5. The latter underwent a series of heterocyclization reactions to give pyridazine, 1,2,3-triazole and pyrazole derivatives. The antitumor evaluation of the newly synthesized products against the three cancer cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCl-H460) and CNS cancer (SF-268) showed that some of them have higher inhibitory effects towards the three cell lines compared to the standard.

引用

页码：1118 / 1121

页数：4

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