Thermal and Reactive Oxygen Species Dual-Responsive OEGylated Polysulfides with Oxidation-Tunable Lower Critical Solution Temperatures

被引：9

作者：

Chen, Runhai ^{[1
,2
]}

Xiang, Zehong ^{[1
,3
]}

Xia, Yu ^{[1
,3
]}

Ma, Zhifang ^{[1
]}

Shi, Qiang ^{[1
]}

Wong, Shing-Chung ^{[4
]}

Yin, Jinghua ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Univ Sci & Technol China, Hefei 230027, Anhui, Peoples R China

[4] Univ Akron, Dept Mech Engn, Akron, OH 44325 USA

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2020年 / 41卷 / 13期

基金：

中国国家自然科学基金;

关键词：

antioxidation; polysulfides; reactive oxygen species; ring-opening polymerization; stimuli-responsive polymers; RING-OPENING POLYMERIZATION; MOLECULAR-WEIGHT; THERMOSENSITIVE POLYMERS; ROS; SURFACE; HOMOPOLYMERS; COPOLYMERS; THIIRANES; HEMOLYSIS; HYDROGELS;

D O I：

10.1002/marc.202000206

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this work, two monomethoxy oligo(ethylene glycol) (OEG)-substituted episulfides are prepared and a series of polysulfides are synthesized with subsequent ring-opening polymerization. The OEGylated polysulfides exhibit thermal and reactive oxygen species (ROS) dual-responsive behavior. Their lower critical solution temperatures (LCSTs) are close to human body temperature and depend on the degree of polymerization and OEG length. Notably, the LCST of the polysulfide increases linearly with the oxidation degree by H2O2, showing a highly tunable change regulated by the ratio between hydrophobic sulfide and hydrophilic sulfoxide/sulfone in the backbone. Further, the OEGylated polysulfide can act as a ROS scavenger to protect red blood cells (RBCs) from oxidative damage in an RBCs aging model in vitro. This work paves a facile way to synthesize LCST-tunable polysulfides, which hold great promise in biological applications.

引用

页数：7

共 54 条

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