Prospective randomized controlled trial of fetal fibronectin on preterm labor management in a tertiary care center

被引:44
作者
Lowe, MP
Zimmerman, B
Hansen, W
机构
[1] Univ Iowa Hosp & Clin, Dept Obstet & Gynecol, Div Maternal Fetal Med, Iowa City, IA 52242 USA
[2] Univ Iowa Hosp & Clin, Dept Biostat, Iowa City, IA 52242 USA
关键词
preterm; fetal fibronectin; length of stay;
D O I
10.1016/j.ajog.2003.08.041
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: The purpose of this study was to investigate the effect of the rapid fetal fibronectin on the length of hospital stay and the use of preterm labor interventions in a tertiary care center. Study design: Women who were seen in the Labor and Delivery Unit with symptoms of preterm labor were assigned randomly to receive fetal fibronectin (n = 46 women) or to preterm labor management without fetal fibronectin (n 51 women). Physicians were not blinded to the result; groups were compared. Results: There was no difference between groups in demographic or obstetric characteristics, the hours spent in labor and delivery, the number of women who were admitted to the antepartum service, the length of stay, or medical interventions. When the results for women with a negative fetal fibronectin test were compared to women with a positive fetal fibronectin test, a significant difference was found in admissions to the antepartum service (P =.032) and the length of stay (P =.008). Conclusions: A negative fetal fibronectin test was associated with fewer admissions to the antepartum ward and a shorter length of stay. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:358 / 362
页数:5
相关论文
共 8 条
[1]   The effect of fetal fibronectin testing on admissions to a tertiary maternal-fetal medicine unit and cost savings [J].
Giles, W ;
Bisits, A ;
Knox, M ;
Madsen, G ;
Smith, R .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2000, 182 (02) :439-442
[2]  
GUYER B, 1995, PEDIATRICS, V96, P1029
[3]   FETAL FIBRONECTIN IMPROVES THE ACCURACY OF DIAGNOSIS OF PRETERM LABOR [J].
IAMS, JD ;
CASAL, D ;
MCGREGOR, JA ;
GOODWIN, TM ;
KREADEN, US ;
LOWENSOHN, R ;
LOCKITCH, G .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1995, 173 (01) :141-145
[4]   FETAL FIBRONECTIN IN CERVICAL AND VAGINAL SECRETIONS AS A PREDICTOR OF PRETERM DELIVERY [J].
LOCKWOOD, CJ ;
SENYEI, AE ;
DISCHE, MR ;
CASAL, D ;
SHAH, KD ;
THUNG, SN ;
JONES, L ;
DELIGDISCH, L ;
GARITE, TJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (10) :669-674
[5]   Predictors of positivity for fetal fibronectin in patients with symptoms of preterm labor [J].
Lukes, AS ;
Thorp, JM ;
Eucker, B ;
PahelShort, L .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1997, 176 (03) :639-641
[6]   THE ONCOFETAL DOMAIN OF FIBRONECTIN DEFINED BY MONOCLONAL-ANTIBODY FDC-6 - ITS PRESENCE IN FIBRONECTINS FROM FETAL AND TUMOR-TISSUES AND ITS ABSENCE IN THOSE FROM NORMAL ADULT TISSUES AND PLASMA [J].
MATSUURA, H ;
HAKOMORI, SI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (19) :6517-6521
[7]   Economic burden of hospitalizations for preterm labor in the United States [J].
Nicholson, WK ;
Frick, KD ;
Powe, NR .
OBSTETRICS AND GYNECOLOGY, 2000, 96 (01) :95-101
[8]   Fetal fibronectin as a predictor of preterm birth in patients with symptoms: A multicenter trial [J].
Peaceman, AM ;
Andrews, WW ;
Thorp, JM ;
Cliver, SP ;
Lukes, A ;
Iams, JD ;
Coultrip, L ;
Eriksen, N ;
Holbrook, RH ;
Elliott, J ;
Ingardia, C ;
Pietrantoni, M .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1997, 177 (01) :13-18