High-performance liquid chromatography integrated solid-phase extraction in bioanalysis using restricted access precolumn packings

被引：118

作者：

Boos, KS ^{[1
]}

Grimm, CH ^{[1
]}

机构：

[1] Univ Hosp Grosshadern, Inst Clin Chem, D-81366 Munich, Germany

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 1999年 / 18卷 / 03期

关键词：

restricted access materials; solid-phase extraction; PROSPEKT; sample clean-up;

D O I：

10.1016/S0165-9936(98)00102-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Tailor-made precolumn packings for HPLC integrated extractive clean-up of (bio)fluids are characterized by possessing a defined diffusion barrier and a biocompatible outer particle surface (restricted access materials, RANI). Only analytes of low molecular mass have free access to the binding centers at the inner pore surface, and thus can be retained and extracted selectively. These adsorbents allow the easy, inexpensive installation and economic operation of fully automated coupled-column systems for repetitive on-line solid-phase extraction (SPE), and the subsequent analytical separation of untreated( bio)fluids. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：175 / 180

页数：6

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