Towards a facile synthesis of triarylethanones:: palladium-catalyzed arylation of ketone enolates under homogeneous and heterogeneous conditions

被引：46

作者：

Churruca, F ^{[1
]}

SanMartin, R ^{[1
]}

Carril, M ^{[1
]}

Tellitu, I ^{[1
]}

Domínguez, E ^{[1
]}

机构：

[1] Euskal Herriko Unibertsitatea, Kimika Organikoa Saila II, Zientzi Fak, Bilbao, Spain

来源：

TETRAHEDRON | 2004年 / 60卷 / 10期

关键词：

arylation; ketones; palladium and compounds;

D O I：

10.1016/j.tet.2003.12.065

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catalyzed regioselective alpha-monoarylation of deoxybenzoins and alpha,alpha-diarylation of acetophenones provides general, efficient access to 1,2,2-triarylethanones. After a comprehensive search for suitable experimental conditions to optimize such transformations, both reactions are alternatively conducted by means of either commercially available polymer-anchored catalysts or a very simple homogeneous catalytic system, thus avoiding the use of complex ligands. In addition, the synthesis of deoxybenzoins employing polymer-supported fibrous palladium catalysts is reported for the first time, and the excellent catalyst recycling properties suggest applicability to industrial purposes. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2393 / 2408

页数：16

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