Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review

被引：65

作者：

Khanam, Hena ^{[1
]}

Ali, Abad ^{[1
]}

Asif, Mohd ^{[1
]}

Shamsuzzaman ^{[1
]}

机构：

[1] Aligarh Muslim Univ, Dept Chem, Steroid Res Lab, Aligarh 202002, Uttar Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2016年 / 124卷

关键词：

Protein misfolding; Neurodegenerative; Alzheimer's disease; Perkinson's disease; Prions; SHEET BREAKER PEPTIDES; MICROTUBULE-STABILIZING DRUGS; SOLUBLE AMYLOID OLIGOMERS; MONOAMINE-OXIDASE-B; ALPHA-LIPOIC ACID; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; MOLECULAR-DYNAMICS; TUBULIN POLYMERIZATION; OXIDATIVE STRESS;

D O I：

10.1016/j.ejmech.2016.08.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Neurodegenerative diseases, such as Alzheimer's, Parkinson's, Creutzfeldt-Jacob, Huntington's diseases and amyotrophic lateral sclerosis, are mainly characterized by the massive deposition of misfolded protein aggregates consequent to aberrant production or overexpression of specific proteins. The development of new therapeutics for the treatment of neurodegenerative pathophysiologies currently stands at a crossroads. This presents an opportunity to transition future drug discovery efforts to target disease modification, an area in which much still remains unknown. In this review we examine recent progress in the area of neurodegenerative drug discovery, focusing on some of the most common targets. (C) 2016 Published by Elsevier Masson SAS.

引用

页码：1121 / 1141

页数：21

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