Actions and mode of actions of FGF19 subfamily members

被引：104

作者：

Fukumoto, Seiji ^{[1
]}

机构：

[1] Tokyo Univ Hosp, Dept Med, Div Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan

来源：

ENDOCRINE JOURNAL | 2008年 / 55卷 / 01期

关键词：

hypophosphatemia; hyperphosphatemia; klotho; FGF;

D O I：

10.1507/endocrj.KR07E-002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fibroblast growth factors (FGFs) are Immoral factors with diverse biological functions. While most FGFs were shown to work as local factors regulating cell growth and differentiation, recent investigations indicated that FGF19 subfamily members, FGF15/19, FGF21 and FGF23 work as systemic factors. FGF 15/19 produced by intestine inhibits bile acid synthesis and FGF21 from liver is involved in carbohydrate and lipid metabolism. In addition, FGF23 was shown to be produced by bone and regulate phosphate and vitamin D metabolism. Furthermore, these FGFs require klotho or beta klotho for their actions in addition to canonical FGF receptors. It is possible that these FGFs together with their receptor systems might be targets for novel therapeutic measures in the future.

引用

页码：23 / 31

页数：9

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