Thiol/Disulfide Balance in Older Patients with BCR-ABL Negative Myeloproliferative Neoplasms

被引:3
作者
Koyuncu, Mahmut B. [1 ]
Cavusoglu, Cagatay [2 ]
Basir, Hakan [3 ]
Ilgan, Mustafa [3 ]
Ucar, Mehmet A. [1 ]
Akdeniz, Aydan [1 ]
Tombak, Anil [1 ]
Tiftik, Eyup N. [1 ]
Temel, Gulhan O. [4 ]
Neselioglu, Salim [5 ]
Erel, Ozcan [5 ]
机构
[1] Mersin Univ, Fac Med, Dept Hematol, Mersin, Turkey
[2] Hacettepe Univ, Fac Med, Dept Geriatr, Ankara, Turkey
[3] Mersin Univ, Fac Med, Dept Internal Med, Mersin, Turkey
[4] Mersin Univ, Fac Med, Dept Biostat, Mersin, Turkey
[5] Yildirim Beyazit Univ, Fac Med, Dept Med Biochem, Ankara, Turkey
关键词
oxidative stress; older adults; myeloproliferative neoplasms; ISCHEMIA-MODIFIED ALBUMIN; OXIDATIVE STRESS; POLYCYTHEMIA-VERA; ASXL1; MUTATIONS; CALRETICULIN; HOMEOSTASIS; MAINTENANCE; BIOMARKER; CELLS; ASSAY;
D O I
10.7754/Clin.Lab.2021.210324
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: The trio Essential Thrombocytosis (ET), Polycythemia Vera (PV), and Primary Myelofibrosis (PM) are BCR-ABL negative myeloproliferative neoplasms. All three diseases have the risk of transforming into acute leukemia. Oxidative stress and some genetic mutations increase the risk of leukemic transformation. The median age in patients with ET, PV, and MF is around 64 years, and it is expected to exceed 65 in the coming years. Since oxidative stress increases with age, we aimed to evaluate the oxidative stress parameters in older patients with myeloproliferative neoplasms. Methods: The study included a total of 160 patients (57 patients with Essential Thrombocytosis, 52 patients with Primary Myelofibrosis, and 51 patients with Polycythemia Vera) and 56 healthy controls, aged 65 and over. Ischemia Modified Albumin (IMA) and thiol parameters (native thiol, total thiol, and disulfide) were studied from serum samples taken at the time of diagnosis. Results: The median age of the patients was 69 (65 - 85) years. Patients had higher levels of IMA and lower levels of thiol compared to the control group (p < 0.001). When evaluated according to disease subgroups, it was observed that the highest IMA levels and the lowest thiol levels were in patients with PM (p < 0.001). Higher IMA levels and lower native thiol levels were found in patients with the ASXL1 mutation (p < 0.001). Conclusions: Serum IMA and thiol levels are also significantly changed in older patients with BCR-ABL negative myeloproliferative neoplasia. Changes in these markers are independent of age. Disease-associated mutations such as ASXL1 can also affect the serum levels of these markers.
引用
收藏
页码:2700 / 2706
页数:7
相关论文
共 35 条
[1]   Synergic Crosstalk between Inflammation, Oxidative Stress, and Genomic Alterations in BCR-ABL-Negative Myeloproliferative Neoplasm [J].
Allegra, Alessandro ;
Pioggia, Giovanni ;
Tonacci, Alessandro ;
Casciaro, Marco ;
Musolino, Caterina ;
Gangemi, Sebastiano .
ANTIOXIDANTS, 2020, 9 (11) :1-18
[2]   The role of calreticulin mutations in myeloproliferative neoplasms [J].
Araki, Marito ;
Komatsu, Norio .
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2020, 111 (02) :200-205
[3]   ASXL1 mutations in myeloid neoplasms: pathogenetic considerations, impact on clinical outcomes and survival [J].
Argote, Juliana Alvarez ;
Dasanu, Constantin A. .
CURRENT MEDICAL RESEARCH AND OPINION, 2018, 34 (05) :757-763
[4]   A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia - A preliminary report [J].
Bar-Or, D ;
Lau, E ;
Winkler, JV .
JOURNAL OF EMERGENCY MEDICINE, 2000, 19 (04) :311-315
[5]   ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage [J].
Barzilai, A ;
Rotman, G ;
Shiloh, Y .
DNA REPAIR, 2002, 1 (01) :3-25
[6]   Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders [J].
Baxter, EJ ;
Scott, LM ;
Campbell, PJ ;
East, C ;
Fourouclas, N ;
Swanton, S ;
Vassiliou, GS ;
Bench, AJ ;
Boyd, EM ;
Curtin, N ;
Scott, MA ;
Erber, WN ;
Green, AR .
LANCET, 2005, 365 (9464) :1054-1061
[7]   Dynamic thiol/disulphide homeostasis in patients with basal cell carcinoma [J].
Demirseren, Duriye Deniz ;
Cicek, Cagla ;
Alisik, Murat ;
Demirseren, Mustafa Erol ;
Aktas, Akin ;
Erel, Ozcan .
CUTANEOUS AND OCULAR TOXICOLOGY, 2017, 36 (03) :278-282
[8]   Thiol/disulfide homeostasis: A prognostic biomarker for patients with advanced non-small cell lung cancer? [J].
Dirican, Nigar ;
Dirican, Ahmet ;
Sen, Orhan ;
Aynali, Ayse ;
Atalay, Sule ;
Bircan, Haci Ahmet ;
Ozturk, Onder ;
Erdogan, Serpil ;
Cakir, Munire ;
Akkaya, Ahmet .
REDOX REPORT, 2016, 21 (05) :197-203
[9]   A novel and automated assay for thiol/disulphide homeostasis [J].
Erel, Ozcan ;
Neselioglu, Salim .
CLINICAL BIOCHEMISTRY, 2014, 47 (18) :326-332
[10]   Thiol-disulfide homeostasis in breast cancer patients [J].
Eryilmaz, Mehmet Ali ;
Kozanhan, Betul ;
Solak, Ibrahim ;
Cetinkaya, Cigdem Damla ;
Neselioglu, Salim ;
Erel, Ozcan .
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2019, 15 (05) :1062-1066