Evaluation of Oritavancin Dosing Strategies against Vancomycin-Resistant Enterococcus faecium Isolates with or without Reduced Susceptibility to Daptomycin in an In Vitro Pharmacokinetic/Pharmacodynamic Model

被引：10

作者：

Belley, Adam ^{[1
]}

Arhin, Francis F. ^{[1
]}

Moeck, Greg ^{[1
]}

机构：

[1] Med Co, St Laurent, PQ, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 01期

关键词：

E; faecium; PK/PD; VRE; VanA; daptomycin; oritavancin; vancomycin-resistant; HIGH-DOSE DAPTOMYCIN; MUTATIONS; TRIALS;

D O I：

10.1128/AAC.01873-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The clinical development of nonsusceptibility to the lipopeptide antibiotic daptomycin remains a serious concern during therapy for infections caused by vancomycin-resistant Enterococcus faecium (VREfm). The long-acting lipoglycopeptide oritavancin exhibits potent in vitro activity against VREfm, although its safety and efficacy for treating clinical VREfm infections have not been established. In this study, novel dosing regimens of daptomycin and oritavancin were assessed against both VREfm and daptomycin-nonsusceptible VREfm isolates in an in vitro pharmacokinetic/pharmacodynamic model.

引用

页数：5

共 16 条

[1]

Belley A, 2017, ANTIMICROB AGENTS CH, V61, DOI [10.1128/AAC.01265-17, 10.1128/aac.01265-17]

[2] Pharmacodynamics of a Simulated Single 1,200-Milligram Dose of Oritavancin in an In Vitro Pharmacokinetic/Pharmacodynamic Model of Methicillin-Resistant Staphylococcus aureus Infection [J].

Belley, Adam ;

Arhin, Francis F. ;

Sarmiento, Ingrid ;

Deng, Hong ;

Rose, Warren ;

Moeck, Greg .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (01) :205-211

[3] Pharmacokinetics and tolerability of daptomycin at doses up to 12 milligrams per kilogram of body weight once daily in healthy volunteers [J].

Benvenuto, Mark ;

Benziger, David P. ;

Yankelev, Sara ;

Vigliani, Gloria .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (10) :3245-3249

[4] Multicenter Study of High-Dose Daptomycin for Treatment of Enterococcal Infections [J].

Casapao, Anthony M. ;

Kullar, Ravina ;

Davis, Susan L. ;

Levine, Donald P. ;

Zhao, Jing J. ;

Potoski, Brian A. ;

Goff, Debra A. ;

Crank, Christopher W. ;

Segreti, John ;

Sakoulas, George ;

Cosgrove, Sara E. ;

Rybak, Michael J. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2013, 57 (09) :4190-4196

[5]

Clinical and Laboratory Standards Institute, 2015, Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically Approved Standard, V3rd ed.

[6] Emergence of a daptomycin-non-susceptible Enterococcus faecium strain that encodes mutations in DNA repair genes after high-dose daptomycin therapy [J].