Comparative Analysis of the Chemotherapy-Related Cognitive Impairments in Patients with Breast Cancer: A Community-Based Research

被引:3
作者
Owrangi, Maryam [1 ]
Gholamzadeh, Mohammad Javad [1 ]
Gharamaleki, Maryam Vasaghi [1 ]
Mousavi, Seyedeh Zahra [1 ]
Kamali, Ali-Mohammad [2 ,3 ]
Dehghani, Mehdi [4 ]
Chakrabarti, Prasun [5 ]
Nami, Mohammad [2 ,3 ,6 ,7 ,8 ,9 ]
机构
[1] Shiraz Univ Med Sci, Sch Med, Students Res Comm, Shiraz, Iran
[2] Shiraz Univ Med Sci, Sch Adv Med Sci & Technol, Dept Neurosci, Shiraz, Iran
[3] DANA Brain Hlth Inst, Iranian Neurosci Soc Fars Chapter, Shiraz, Iran
[4] Shiraz Univ Med Sci, Namazi Hosp, Hematol Res Ctr, Dept Hematol & Med Oncol, Shiraz, Iran
[5] ITM SLS Baroda Univ Vadodara, Paldi, India
[6] Senses Cultural Fdn, Acad Hlth, Sacramento, CA USA
[7] Inst Invest Cient & Serv Alta Tecnol INDICASAT AI, Neurosci Ctr, Panama City, Panama
[8] Inst Cognit Sci Studies ICSS, Dept Cognit Neurosci, Tehran, Iran
[9] Soc Brain Mapping & Therapeut SBMT, Los Angeles, CA USA
关键词
Breast cancer; cancer related cognitive impairment (CRCI); cognitive impairment; attention; visuospatial working memory; ADJUVANT CHEMOTHERAPY; RISK-FACTORS; METAANALYSIS; WOMEN; SURVIVORS; DYSFUNCTION; POPULATION; PREVALENCE; VALIDATION; DEPRESSION;
D O I
10.1080/07357907.2022.2106489
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This study aimed to evaluate the effects of two common chemotherapy regimens on breast cancer (BC) survivors' cognition. The participants comprised 35 patients with BC who underwent two chemotherapy regimens, AC-T and TAC, and 24 matched healthy volunteers. The participants were assessed regarding cognitive function through Addenbrooke's Cognitive Examination and Cambridge Brain Science tests. The results represent the AC-T regimen to be more toxic than the TAC in domains of language, concentration, and visuospatial working memory (P-value = 0.036, 0.008, and 0.031, respectively) and should be prescribed with caution in patients with BC suffering from baseline cognitive impairments.
引用
收藏
页码:811 / 821
页数:11
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